Antidepressants, Antimanics drugs

Manic depressive disorder, also known as affective disorders, is a kind of mental illness with its symptoms being emotional pathological changes. Manic-depressive disorder is characterized by repeated episodes of either manic or depressive episodes (single phase), or alternatively both of episodes (bipolar). The cause may be related to the brain monoamine dysfunction. However, the 5 - HT deficiency is the common biochemical basis. On this basis, upon NA (norepinephrine) hyperactivity, patients exhibits manic performance. Upon pathogenesis, patients are characterized by high mood, quick thinking and increased activities. NA dysfunction is manifested as depression. The patients will exhibit depression with reduced speech, reduced mental activity, bradykinesia and often self-blame and even attempt to suicide. The treatment of this disease is mainly symptomatic treatment with the main drugs being divided into antidepressant and anti-mania drugs. Commonly used antidepressants are tricyclic tetracyclines, including imipramine, desipramine, doxepin, amitriptyline, mianserin and maprotiline, etc. The major difference in the chemical structure of them with phenothiazine drugs is the substitution of the S atom with -CH2-CH2-.

These drugs are mainly used for the treatment of various types of depression. It has better efficacy in the treatment of the endogenous, reactive and menopausal depression, while being less effective in the treatment of the depression of schizophrenia. The most common adverse reactions exhibits atropine-like behavior such as dry mouth, constipation, blurred vision, palpitations and so on. A typical anti-mania agent is a lithium formulation. Lithiuim salt in treatment amount had almost little effect on the mental activity of normal people, but having significant effect on the mania patients, restoring the speech, behavior of patients to normal condition. Experiments have shown that lithium can inhibit the NA and DA release of brain while boosting its reuptake, causing the decrease concentration of NA in the synaptic cleft and resulting in anti-manic effect. There are many adverse reactions of lithium salt and the adverse reactions have individual differences. Other drugs such as chlorpromazine, haloperidol and anti-epileptic drug carbamazepine are also effective against mania.

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Structure Chemical Name CAS MF
Citalopram hydrobromide Citalopram hydrobromide 59729-32-7 C20H22BrFN2O
Yohimbine hydrochloride Yohimbine hydrochloride 65-19-0 C21H27ClN2O3
Escitalopram oxalate Escitalopram oxalate 219861-08-2 C22H23FN2O5
Venlafaxine Venlafaxine 93413-69-5 C17H27NO2
4-Chlorobutyl methyl ether 4-Chlorobutyl methyl ether 17913-18-7 C5H11ClO
5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone 61718-80-7 C13H15F3O2
AGOMELATINE AGOMELATINE 138112-76-2 C15H17NO2
Sertraline hydrochloride Sertraline hydrochloride 79559-97-0 C17H18Cl3N
Lithium carbonate Lithium carbonate 554-13-2 CLi2O3
Amitriptyline hydrochloride Amitriptyline hydrochloride 549-18-8 C20H24ClN
HEMATOPORPHYRIN DIHYDROCHLORIDE HEMATOPORPHYRIN DIHYDROCHLORIDE 17696-69-4 C34H40Cl2N4O6
Paroxetine hydrochloride Paroxetine hydrochloride 78246-49-8 C19H21ClFNO3
FLUOXETINE HYDROCHLORIDE FLUOXETINE HYDROCHLORIDE 59333-67-4 C17H19ClF3NO
Doxepin hydrochloride Doxepin hydrochloride 1229-29-4 C19H22ClNO
Clomipramine hydrochloride Clomipramine hydrochloride 17321-77-6 C19H24Cl2N2
17alpha-Hydroxy-yohimban-16alpha-carboxylic acid methyl ester 17alpha-Hydroxy-yohimban-16alpha-carboxylic acid methyl ester 146-48-5 C21H26N2O3
Trazodone hydrochloride Trazodone hydrochloride 25332-39-2 C19H23Cl2N5O
Sibutramine hydrochloride Sibutramine hydrochloride 84485-00-7 C17H27Cl2N
Moclobemide Moclobemide 71320-77-9 C13H17ClN2O2
Phenelzine Phenelzine 51-71-8 C8H12N2
Amitriptyline Amitriptyline 50-48-6 C20H23N
PAROXETINE-D4 HCL PAROXETINE-D4 HCL 110429-35-1 C19H17ClD4FNO3
NORTRIPTYLINE NORTRIPTYLINE 72-69-5 C19H21N
3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one 7416-34-4 C16H24N2O2
PHENELZINE SULFATE SALT PHENELZINE SULFATE SALT 156-51-4 C8H14N2O4S
IMIPRAMINE IMIPRAMINE 50-49-7 C19H24N2
Fluvoxamine maleate Fluvoxamine maleate 61718-82-9 C19H25F3N2O6
DESIPRAMINE DESIPRAMINE 50-47-5 C18H22N2
Fluoxetine Fluoxetine 54910-89-3 C17H18F3NO
ISOCARBOXAZID (200 MG) ISOCARBOXAZID (200 MG) 59-63-2 C12H13N3O2
Trazodone Trazodone 19794-93-5 C19H22ClN5O
Metapramine Metapramine 21730-16-5 C16H18N2
Mianserin hydrochloride Mianserin hydrochloride 21535-47-7 C18H21ClN2
TRIMIPRAMINE TRIMIPRAMINE 739-71-9 C20H26N2
DESIPRAMINE HYDROCHLORIDE DESIPRAMINE HYDROCHLORIDE 58-28-6 C18H23ClN2
DOXEPIN DOXEPIN 1668-19-5 C19H21NO
Sertraline Sertraline 79617-96-2 C17H17Cl2N
Clomipramine Clomipramine 303-49-1 C19H23ClN2
Paroxetine Paroxetine 61869-08-7 C19H20FNO3
Citalopram Citalopram 59729-33-8 C20H21FN2O
Fluoxetine hydrochloride Fluoxetine hydrochloride 56296-78-7 C17H19ClF3NO
NOMIFENSINE MALEATE NOMIFENSINE MALEATE 24526-64-5 C16H18N2
Sibutramine Sibutramine 106650-56-0 C17H26ClN
Asenapine Asenapine 65576-45-6 C17H16ClNO
Maprotiline Maprotiline 10262-69-8 C20H23N
Maprotiline hydrochloride Maprotiline hydrochloride 10347-81-6 C20H24ClN
Reboxetine Reboxetine 98769-81-4 C19H23NO3
Melitracen Melitracen 5118-29-6 C21H25N
NORTRIPTYLINE HYDROCHLORIDE NORTRIPTYLINE HYDROCHLORIDE 894-71-3 C19H22ClN
Fluvoxamine Fluvoxamine 54739-18-3 C15H21F3N2O2
2-OXAZOLIDINONE, 5-(HYDROXYMETHYL)-3-(3-METHYLPHENYL)- 2-OXAZOLIDINONE, 5-(HYDROXYMETHYL)-3-(3-METHYLPHENYL)- 29218-27-7 C11H13NO3
Melitracen hydrochloride Melitracen hydrochloride 10563-70-9 C21H26ClN
HEMATOPORPHYRIN HEMATOPORPHYRIN 14459-29-1 C34H38N4O6
LITHIUM CITRATE LITHIUM CITRATE 919-16-4 C6H5Li3O7
Hematoprophyrin Hematoprophyrin C34H38N4O6
MOLINDONE HCL MOLINDONE HCL
NORTRIPTYLINE HCL(USP)(COMING SOON)(P) NORTRIPTYLINE HCL(USP)(COMING SOON)(P)
Mianserin Mianserin
Flubanilate Flubanilate 847-20-1 C14H19F3N2O2
carpipramine carpipramine 5942-95-0 C28H38N4O
carpipramine dihydrochloride carpipramine dihydrochloride 7075-03-8 C28H38N4O.2ClH.H2O
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