Product Details
| Product Name: Calcium Gluconate | CAS No.: 299-28-5 |
| EC-No.: 206-075-8 | Min. Order: 1ton |
| Purity: 99% | Supply Ability: 1000T/M |
| Release date: 2025/09/23 |
Product Name: Calcium Gluconate
Synonyms: D-Gluconic acid calcium salt; Calcium D-gluconate
CAS No.: 299-28-5
EC / EINECS No.: 206-075-8
Molecular Formula: C₁₂H₂₂CaO₁₄
Molecular Weight: ~430.37 g/mol
Chemical Nature: Calcium salt of gluconic acid
Appearance: White to off-white crystalline powder or granules, odorless, tasteless
1. General Properties
Calcium Content (dry basis): ~9.0%
Solubility: Freely soluble in hot water; slightly soluble in cold water; insoluble in ethanol
pH (10% solution): ~6.0 – 8.0
Bulk Density: ~0.5–0.7 g/mL
Loss on Drying: Typically ≤1.5%
Melting Point: Decomposes on heating
2. Specifications by Grade
A. Industrial / Technical Grade
| Parameter | Typical Specification |
|---|---|
| Appearance | White to off-white powder |
| Assay (as CaC₁₂H₂₂O₁₄) | ≥ 98.0 % |
| Elemental Calcium | ≥ 9.0 % |
| Loss on Drying | ≤ 1.5 % |
| pH (10% solution) | 6.0 – 8.5 |
| Heavy Metals (as Pb) | ≤ 20 ppm |
| Lead (Pb) | ≤ 10 ppm |
| Arsenic (As) | ≤ 3 ppm |
| Chloride | ≤ 0.05 % |
| Sulfate | ≤ 0.05 % |
| Mesh Size | Pass 80 mesh |
| Microbiology | Not routinely controlled (industrial applications) |
B. Food / Pharma / Nutraceutical Grade
| Parameter | Typical Specification |
|---|---|
| Appearance | White crystalline powder or granules |
| Identification | IR spectrum / wet chemistry conforms |
| Assay (as CaC₁₂H₂₂O₁₄) | 98.0 – 102.0 % |
| Elemental Calcium | 9.0 – 9.5 % |
| Loss on Drying | ≤ 1.0 % |
| pH (10% solution) | 6.0 – 8.0 |
| Chloride | ≤ 0.04 % |
| Sulfate | ≤ 0.04 % |
| Heavy Metals (total) | ≤ 10 ppm |
| Lead (Pb) | ≤ 1 ppm |
| Arsenic (As) | ≤ 0.5 ppm |
| Cadmium (Cd) | ≤ 0.5 ppm |
| Mercury (Hg) | ≤ 0.1 ppm |
| Reducing Substances | Pass |
| Mesh Size | Pass 80 – 100 mesh |
| Microbiology | TPC ≤ 1,000 cfu/g; Yeast & Mold ≤ 100 cfu/g; Salmonella absent (25 g); E. coli absent (10 g) |
| Certifications | FCC / USP / EP compliant, Kosher / Halal available |
3. Analytical Methods
Assay & Calcium Content: Complexometric titration (EDTA) or ICP-MS
LOD: Gravimetric (105 °C to constant weight)
pH: 10% solution at 25 °C
Heavy Metals: ICP-MS or AAS
Microbiology: ISO or USP standard methods
4. Manufacturing Process Summary
Process: Fermentation of glucose to gluconic acid → neutralization with calcium carbonate or calcium hydroxide → concentration → crystallization → drying → milling & sieving
Control: In-process monitoring of pH, purity, residual impurities, and microbial load (for food/pharma grade)
Grades: Technical grade for industrial chemical use; food/pharma grade produced under HACCP, GMP conditions
5. Packaging & Storage
Packaging:
Industrial: 25 kg kraft paper bags with PE inner liner, bulk FIBC available
Food/Pharma: Multi-layer moisture-proof bags, 25 kg net; smaller packs available
Storage: Store in cool, dry place; humidity <60%; avoid direct sunlight
Shelf Life: 24 – 36 months under recommended storage
6. Safety & Handling
Hazards: Considered low toxicity; dust may irritate respiratory tract
PPE: Goggles, dust mask, gloves during handling
First Aid:
Eyes: Flush with water
Skin: Wash with soap and water
Inhalation: Fresh air
Ingestion: Rinse mouth; seek medical attention if large amounts consumed
Regulatory: Generally Recognized as Safe (GRAS) for food applications (21 CFR 184.1199)
7. Applications
Industrial: Calcium fortification in animal feed, buffer solutions, chemical intermediate
Food / Beverage: Calcium fortification in dairy products, beverages, cereals
Nutraceutical: Dietary calcium supplement (tablets, powders, effervescent)
Pharma: Calcium source in injectables (calcium gluconate injection), oral supplements
8. Example CoA (Food Grade, Typical Values)
| Parameter | Result | Specification |
|---|---|---|
| Appearance | White crystalline powder | Pass |
| Assay | 99.0 % | 98.0 – 102.0 % |
| Elemental Calcium | 9.3 % | 9.0 – 9.5 % |
| Loss on Drying | 0.45 % | ≤ 1.0 % |
| pH (10%) | 7.0 | 6.0 – 8.0 |
| Pb | < 0.2 ppm | ≤ 1 ppm |
| As | < 0.05 ppm | ≤ 0.5 ppm |
| Cd | < 0.02 ppm | ≤ 0.5 ppm |
| Hg | ND | ≤ 0.1 ppm |
| TPC | 60 cfu/g | ≤ 1,000 cfu/g |
| Salmonella | Absent | Absent |
| E. coli | Absent | Absent |
For more information, please click on the website：http://www.khonorchem.com
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- Address: C-309, No. 12 Yuzhou S. Rd, Haizhou, Lianyungang, Jiangsu, China