Cloperastine inhibits the hERG K + currents in a concentrationdependent manner | China | Manufacturer

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Product Name: Cloperastine hydrochloride	CAS No.: 14984-68-0
EC-No.: 239-067-8	Min. Order: 1kg
Purity: 99.99%	Supply Ability: 20 tons
Release date: 2025/08/20

Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM.Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

Intheanesthetizedguineapigs,Cloperastineatatherapeuticdoseof1mg/kgprolongedtheQTintervalandmonophasicactionpotential(MAP)durationwithoutaffectingPRintervalorQRSwidth.CloperastinehydrochlorideshowsrelativelylowacutetoxicChemicalbookitywhenadministeredbytheintraperitonealrouteinratsandmice,andshowsminortoxicitybytheoralroutewhenadministeredasCloperastinefendizoate,theLD50inratsandmiceforthetwoadministrationroutesexceeds1000and2000mg/kg,respectively.

Brand: Soarwin

CAS No.:14984-68-0

EC Number:239-067-8

Molecular Formula: C20H25Cl2NO

Melting point:147.9°

Company Profile Introduction

Chongqing Soarwin Technology Co., Ltd is located in Chongqing. It is an enterprise dedicated to the research, development, production, and sales of chemical reagents, pharmaceutical intermediates, plant extracts, and chemical raw materials. It is a pharmaceutical company guided by the global pharmaceutical market demand and integrates innovative drug research and development, industrialization, and market operation. At present, the company has submitted 10 domestic patents and 1 PCT patent (international patent); and obtained 7 invention patents. The company has strong technical strength, advanced equipment, a strict quality management system, and high-quality after-sales service.

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Cloperastine hydrochloride	$1.00/1kg	VIP8Y	Career Henan Chemical Co	2018-12-22

Cloperastine hydrochloride

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Chongqing Soarwin Technology Co., Ltd