Dapoxetine hydrochloride NEW

Chinese name: Dapoxetine hydrochloride

English name :Dapoxetine hydrochloride

CAS:129938-20-1

Molecular formula :C9H7ClN2O5

MDL number :MFCD08272809

Molecular weight :258.62

Appearance: White to white powder.

Melting point :175-1790C

Specific rotation :D +135.78° (c = 2.18 in methanol)

Storage condition :room temp

Solubility: dimethyl sulfoxide: ≥20mg/mL

Form: Powder

Color: White

optical activity :[α]/D +125 to +135°, c = 1 in methanol

Merck: 1 14282

InChI:InChI=1/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21; / h3-14, 20 H, 15 to 16 h2, 1-2 h3; 1H/t20-; /s3

InChIKey:IHWDIQRWYNMKFM-OZYVVJTJNA-N

SMILES:O(C1=CC=CC2C=CC=CC1=2)CC[C@@H](C1C=CC=CC=1)N(C)C.Cl |&1:13,r|

nature

Dapoxetine hydrochloride is white to white powder. It is easily soluble in methanol and ethanol, slightly soluble in dichloroethane, and almost insoluble in water. Dapoxetine hydrochloride is a BCSII compound, and poor solubility is the key factor affecting the difference of clinical efficacy. Dapoxetine hydrochloride exists in a variety of crystal forms, and the solubility of different crystal forms is very different, and there is phase and transformation between the crystal forms.

use

Dapoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI).