Domperidone
| Price | $10 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | Ex 20 tons |
| Update Time: | 2022-10-14 |
Product Details
| Product Name: Domperidone | CAS No.: 57808-66-9 |
| EC-No.: 260-968-7 | Min. Order: 1kg |
| Purity: 99% | Supply Ability: Ex 20 tons |
| Release date: 2022/10/14 |
Use of Domperidone
Domperidone is a dopamine blocker and an antidopaminergic reagent.Target: Dopamine ReceptorDomperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability. Effectiveness and side-effects from domperidone may be influenced by patient-related factors including polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and domperidone targets [1]. Domperidone is a dopamine D(2) receptor antagonist, which has been used as antiemetic agent in human beings. The percentage recovery of domperidone from wastewater was 95.0%. Celiprolol was used as the internal standard to access the percentage extraction of domperidone from wastewater [2]. Domperidone, a dopamine antagonist that does not easily cross the blood-brain barrier, is considered the gold standard for treating gastrointestinal symptoms in patients with Parkinson's disease (PD) because the risk of developing extrapyramidal adverse effects is considered minimal [3].
| Name | Domperidone |
|---|---|
| Synonym | More Synonyms |
| Description | Domperidone is a dopamine blocker and an antidopaminergic reagent.Target: Dopamine ReceptorDomperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability. Effectiveness and side-effects from domperidone may be influenced by patient-related factors including polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and domperidone targets [1]. Domperidone is a dopamine D(2) receptor antagonist, which has been used as antiemetic agent in human beings. The percentage recovery of domperidone from wastewater was 95.0%. Celiprolol was used as the internal standard to access the percentage extraction of domperidone from wastewater [2]. Domperidone, a dopamine antagonist that does not easily cross the blood-brain barrier, is considered the gold standard for treating gastrointestinal symptoms in patients with Parkinson's disease (PD) because the risk of developing extrapyramidal adverse effects is considered minimal [3]. |
|---|---|
| Related Catalog | Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease |
| Solvent | In Vitro: 10 mM in DMSO |
| Solubility | 1 mM2.3479 mL11.7396 mL23.4791 mL5 mM0.4696 mL2.3479 mL4.6958 mL10 mM0.2348 mL1.1740 mL2.3479 mL |
| Storage | Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 month |
| Shipping | Room temperature in continental US; may vary elsewhere |
| SMILES | O=C1NC2=CC(Cl)=CC=C2N1C3CCN(CCCN4C5=CC=CC=C5NC4=O)CC3 |
| References | [1]. Parkman, H.P., et al., Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects. Dig Dis Sci, 2011. 56(1): p. 115-24. [2]. Ali, I., et al., Screening of domperidone in wastewater by high performance liquid chromatography and solid phase extraction methods. Talanta, 2006. 68(3): p. 928-31. [3]. Lertxundi, U., et al., Domperidone in Parkinson's disease: a perilous arrhythmogenic or the gold standard. Curr Drug Saf, 2013. 8(1): p. 63-8. |
| Related Molecules | CB-154 mesylate | SCH 23390 hydrochloride | Levodopa | Cabergoline | Thioridazine hydrochloride | Brexpiprazole | Trifluoperazine dihydrochloride | pimozide | Risperidone | SKF38393 HCl | Cariprazine | SERTINDOLE | Fluphenazine (dihydrochloride) | Nomifensine | Ropinirole hydrochloride |
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China- Since: 2022-02-24
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