Donepezil HCl

🌟 ‌Donepezil Hydrochloride (CAS 120011-70-3) - Product Overview‌
Donepezil Hydrochloride is a ‌highly selective acetylcholinesterase (AChE) inhibitor‌ (molecular formula: ‌C₂₄H₃₀ClNO₃‌, MW: 415.95) primarily used to ‌treat mild to moderate Alzheimer’s disease (AD)‌. This white crystalline powder with ≥99% HPLC purity enhances cognitive function by elevating acetylcholine levels in the brain, offering stability under ‌2-8°C storage conditions‌ for pharmaceutical formulations.

🔑 ‌Key Advantages‌
✔️ ‌Potent Inhibition‌: Targets AChE with an IC₅₀ of ‌6.7 nM‌, outperforming traditional inhibitors.
✔️ ‌Clinical Efficacy‌: Improves ADAS-cog scores by ‌3-4 points‌ in clinical trials.
✔️ ‌Versatile Solubility‌: >50 mg/mL water solubility for easy formulation.
✔️ ‌Safety Edge‌: Minimizes peripheral cholinergic side effects.

📋 ‌Applications‌

• ‌Alzheimer’s Therapy‌: Core treatment for slowing cognitive decline.

• ‌Neurological Research‌: Key tool for studying cholinergic pathways.

• ‌Drug Development‌: Used in extended-release tablets and combination therapies.

🏅 ‌Quality Certifications‌

• Complies with ‌USP/EP‌ pharmacopeial standards.

• Batch-tested via ‌HPLC (≥99%)‌, ‌GC‌, and ‌NMR‌for structural validation.

• Manufactured in ‌GMP‌-certified facilities with ISO 9001 compliance.

📈 ‌Market Insights‌
The global Alzheimer’s treatment market is projected to surpass ‌$8 billion by 2030‌, driven by aging populations. Donepezil Hydrochloride dominates ‌40% of the AChE inhibitor market‌, maintaining its status as a first-line therapy.