EUK-134 NEW
| Price | $30 | $0.9 |
| Package | 1KG | 1000KG |
| Min. Order: | 1KG |
| Supply Ability: | g-kg-tons, free sample is available |
| Update Time: | 2024-04-27 |
Product Details
| Product Name: EUK-134 | CAS No.: 81065-76-1 |
| Min. Order: 1KG | Purity: 99% |
| Supply Ability: g-kg-tons, free sample is available | Release date: 2024/04/27 |
| Lead time: In stock | Packaging: bottle/drum/bucket/IBC, as request. |
| Delivery: By sea, by air, by express | Origin: Manufacturer |
| Contact: Light |
1. Product information
Use of EUK-134EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3]. |
| Name | manganese(2+),2-methoxy-6-[2-[(3-methoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride |
|---|---|
| Synonym | More Synonyms |
| Description | EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >> Cardiovascular Disease |
| Target | NF-κB |
| In Vitro | EUK-134 (10-300 μM) is able to improve cell viability and reduces Paraquat (1 mM)-induced cell death significantly via dismutation or scavenging of superoxide anions and reduces hydroxyl radical generation[2]. Higher concentrations of EUK-134 alone (30-300 μM) produces modest but significant reductions in cellular viability; however, this effect is not reflected in cell death measurements made at these concentrations[2]. EUK-134 is a salen-manganese complex with superoxide dismutase and catalase activity.Supplementation with EUK-134 is therefore identified as a novel approach to attenuate cardiac hypertrophy and lends scope for the development of EUK-134 as a therapeutic agent in the management of human cardiovascular disease.EUK-134 is a mitoprotective antioxidant with Mn-superoxide dismutase (Mn SOD) and catalase activity[3]. Cell Viability Assay[2] Cell Line: NRK-52E cells Concentration: 0, 1, 3, 10, 30, 100, and 300 μM Incubation Time: 24 hours Result: Co-incubation with Paraquat (1 mM) and increasing concentrations of EUK-134 (1-300 μM) resulted in a significant reduction in paraquat-induced cellular injury and death at 100 and 300 μM. |
| References | [1]. P Gianello, et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 1996 Dec 15;62(11):1664-6. [2]. Mohamed Samai, et al. Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity. Free Radic Biol Med. 2007 Aug 15;43(4):528-34. [3]. Sreeja Purushothaman, et al. Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. Mol Cell Biochem. 2016 Sep;420(1-2):185-94. |
| Molecular Formula | C18H18ClMnN2O4 |
|---|---|
| Molecular Weight | 416.738 |
| Exact Mass | 416.033569 |
| PSA | 58.62000 |
| LogP | 3.09010 |
| Appearance of Characters | , faint to very dark brown |
| Storage condition | ?20°C |
| Water Solubility | H2O: soluble2mg/mL, clear (warmed) |
EUK-134 MSDS(Chinese) |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
For more details, pls contact us freely.
Mob: 86 15617686737
WhatsApp/Skype/Wechat: 86 15617686737.
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China
- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro