ExeMestane(AroMasin)
| Price | $9.9 | $3489 |
| Package | 1g | 1000g |
| Min. Order: | 1g |
| Supply Ability: | 2 tons |
| Update Time: | 2024-04-19 |
Product Details
| Product Name: ExeMestane(AroMasin) | CAS No.: 107868-30-4 |
| Min. Order: 1g | Purity: 99.99% |
| Supply Ability: 2 tons | Release date: 2024/04/19 |
| Description | Exemestane was launched in US and other countries for the treatment of estrogendependent tumors and postmenopausal breast cancer. It is a novel steroidal compound structurally related to the natural substrate for the biosynthesis of estrogen, androstanedione, and can be synthesized by methylidenation of androsta-1, 4-dien- 17beta-ol-3-one in 6 position then oxidation of the alcohol function. Exemestane is an irreversible inactivator of the aromatase enzyme system, so inducing in vivo a dose-related sustained suppression of serum estrogen and minimal endocrine activity. It is the first steroidal representative of the third-generation of orally active aromatase inhibitors with a highly potent and selective mechanism of action, displaying good tolerability and safety profile. In rats with DMBA-induced mammary tumors, 10 to 100 mglkg of exemestan administered po twice-daily for 4 weeks resulted in 76 to 88% regression. In women failing anti-estrogen therapy with tamoxifen, this agent has demonstrated high activity in locally advanced or metastatic disease. In addition, it may also have potential for breast cancer prevention. |
| Chemical Properties | white to light yellow crystal powder |
| Originator | Farmitalia Carlo Erba (Italy) |
| Uses | An antineoplastic (hormonal) |
| Uses | antiinfective |
| Uses | Labeled Exemestane, intended for use as an internal standard for the quantification of Exemestane by GC- or LC-mass spectrometry. |
| Description | Exemestane was launched in US and other countries for the treatment of estrogendependent tumors and postmenopausal breast cancer. It is a novel steroidal compound structurally related to the natural substrate for the biosynthesis of estrogen, androstanedione, and can be synthesized by methylidenation of androsta-1, 4-dien- 17beta-ol-3-one in 6 position then oxidation of the alcohol function. Exemestane is an irreversible inactivator of the aromatase enzyme system, so inducing in vivo a dose-related sustained suppression of serum estrogen and minimal endocrine activity. It is the first steroidal representative of the third-generation of orally active aromatase inhibitors with a highly potent and selective mechanism of action, displaying good tolerability and safety profile. In rats with DMBA-induced mammary tumors, 10 to 100 mglkg of exemestan administered po twice-daily for 4 weeks resulted in 76 to 88% regression. In women failing anti-estrogen therapy with tamoxifen, this agent has demonstrated high activity in locally advanced or metastatic disease. In addition, it may also have potential for breast cancer prevention. |
| Chemical Properties | white to light yellow crystal powder |
| Originator | Farmitalia Carlo Erba (Italy) |
| Uses | An antineoplastic (hormonal) |
| Uses | antiinfective |
| Uses | Labeled Exemestane, intended for use as an internal standard for the quantification of Exemestane by GC- or LC-mass spectrometry. |
Advantage:
1. Our company is a professional production leading factory in China in pharmaceutical area of many years. Delivery areas of our products:US, UK, Canada, Australia, Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium, Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Thailand, Israel and so on.
Payment method: T/T, Western union, Moneygram.
2. Discreet package.The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration.
3. Top quality. High quality guarenteed, once any problem is found, the package would be reshipped for
you.
4. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
5. We have stock, so we can delivery quickly at the very day when receive the payment.
6. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as
possible.
7. A discount would be given when you make a large order.
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China- Since: 2023-03-16
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