Hormonal antineoplastic drugs

Hormonal antineoplastic drugs of action is usually considered to function by binding with specific hormone receptors. Hormone receptors, all of which are cytoplasmic protein and nucleoprotein, combined with the hormone with high affinity and specificity. After penetrating the cell membrane and getting into the cells, endogenous or exogenous steroids bind to specific receptors and form the hormone-receptor complexes and activated into the nucleus. The activated hormone receptor complexes, binding to specific receptors of chromatin, react with the role of various components of the nucleus, which causes DNA replication and cell division by a series of enzymatic reactions, thus affecting the physiological function of cells. Adrenocorticotropic hormone, that works on lymphocytes, making it dissolve directly and inhibiting mitosis role, plays an important role in the treatment of lymphoma, leukemia and multiple myeloma. It should be attached care in the use of hormone to treat related tumors, and the hormone must be selected carefully by theoretical basis, in line with the indications, and with dosage properly, otherwise it will promote the growth of tumor cells, just the opposite. This antineoplastic drugs include aromatase inhibitors, aromatase inactivator, estrogens, anti-estrogens, progestins, androgens, anti-androgens, luteinizing hormone agonists, glucocorticoids hormones, adrenal blockers and others.

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Structure Chemical Name CAS MF
Raloxifene Raloxifene 84449-90-1 C28H27NO4S
Exemestane Exemestane 107868-30-4 C20H24O2
Letrozole Letrozole 112809-51-5 C17H11N5
Fulvestrant Fulvestrant 129453-61-8 C32H47F5O3S
Anastrozole Anastrozole 120511-73-1 C17H19N5
Droloxifene Droloxifene 82413-20-5 C32H37NO9
Flutamide Flutamide 13311-84-7 C11H11F3N2O3
Tamoxifen citrate Tamoxifen citrate 54965-24-1 C32H37NO8
Formestane Formestane 566-48-3 C19H26O3
Nilutamide Nilutamide 63612-50-0 C12H10F3N3O4
IDOXIFENE IDOXIFENE 116057-75-1 C28H30INO
Aminoglutethimide Aminoglutethimide 125-84-8 C13H16N2O2
Toremifene Toremifene 89778-26-7 C26H28ClNO
Tamoxifen Tamoxifen 10540-29-1 C26H29NO
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