GSK-3β inhibitor 3 NEW
| Price | $50 | $119 | $178 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-14 |
Product Details
| Product Name: GSK-3β inhibitor 3 | CAS No.: 1448990-73-5 |
| Purity: 97.53% | Supply Ability: 10g |
| Release date: 2026/07/14 |
Product Introduction
Bioactivity
| Name | GSK-3β inhibitor 3 |
| Description | GSK-3β inhibitor 3 is a potent, selective, and irreversible covalent inhibitor of glycogen synthase kinase 3β (GSK-3β) with an IC50 of 6.6 μM, and can be used to study acute promyelocytic leukemia. |
| In vitro | GSK-3β inhibitor 3 (compound 4-3) (6.25-100 μM; 24-48 h) dose-dependently inhibits cell viability, with IC50s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. It (12.5-100 μM; 24 h) also significantly increases apoptosis in a dose-dependent manner in NB4 and NB4-R1 cells. Additionally, GSK-3β inhibitor 3 (100 μM) inhibits GSK-3α activity by 87.3%.[1] |
| In vivo | GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg; a single i.p.; Balb/c female nude mice) demonstrates a T1/2 of 14.2 hours, an AUClast of 3503.42 ng/mL•h, and a Cmax of 515 ng/mL in mice.[1] Additionally, GSK-3β inhibitor 3 (15 mg/kg/d; i.p. for 2 weeks; Balb/c female nude mice) inhibits tumor growth by 75.97% compared to the vehicle control.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 225 mg/mL (687.3 mM), Sonication is recommended. |
| Keywords | GSK-3β inhibitor 3 | GSK3β inhibitor 3 | GSK-3β | GSK-3beta inhibitor 3 | GSK-3b inhibitor 3 | GSK3 | GSK 3β inhibitor 3 | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Ethyl linoleate | Formamide | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Glycometabolism Compound Library | Cysteine Covalent Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $58.00 |
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-07-14 | |
| $2500.00 |
VIP2Y
|
TargetMol Chemicals Inc.
|
2026-05-11 | |
| $80.00 |
VIP3Y
|
Zibo Hangyu Biotechnology Development Co., Ltd
|
2026-07-06 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY