Heparin lithium salt NEW

Heparin lithium salt

Modify Date: 2024-01-04 08:29:31

Heparin lithium salt structure	Common Name	Heparin lithium salt
	CAS Number	9045-22-1	Molecular Weight	148.159
	Density	1.2±0.1 g/cm3	Boiling Point	265.0±0.0 °C at 760 mmHg
	Molecular Formula	(C14H25NO20S3)n.xLi	Melting Point	N/A
	MSDS	ChineseUSA	Flash Point	189.5±9.6 °C

Purity		Quantity		Budget		Inquiry

Use of Heparin lithium salt Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII).

• Properties

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• Spectrum

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 Names

Name	Heparin lithium salt
Synonym	More Synonyms

 Heparin lithium salt Biological Activity

Description	Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII).
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Others
Target	Antithrombin III[1]
In Vitro	Heparin is a potent anticoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. Heparin interactes most tightly with peptides containing a complementary binding site of high positive charge density. Heparin resembles DNA as both are highly charged linear polymers that behave as polyelectrolytes. Heparin is believed to function as an anticoagulant primarily through its interaction with AT III by enhancing AT-III-mediated inhibition of blood coagulation factors, including thrombin and factor Xa. Heparin binds to AT III and thrombin in a ternary complex, increasing the bimolecular rate constant for the inhibition of thrombin by a factor of 2000. Heparin is principally located in the granules of tissue mast cells that are closely associated with the immune response. Heparin makes numerous contacts with both FGF-2 and FGFR-1 stabilizing FGF–FGFR binding. Heparin also makes contacts with the FGFR-1 of the adjacent FGF–FGFR complex, thus seeming to promote FGFR dimerization[1].
References	[1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.

 Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	265.0±0.0 °C at 760 mmHg
Molecular Formula	(C14H25NO20S3)n.xLi
Molecular Weight	148.159
Flash Point	189.5±9.6 °C
Exact Mass	148.052429
LogP	2.41
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.616
Storage condition	+15C to +30C

 Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	22-24/25-36-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MI0700000
HS Code	29319090

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