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Postion:Product Catalog >Biochemical Engineering>Amino Acids and Derivatives>Tryptophan derivatives>L-5-Hydroxytryptophan
L-5-Hydroxytryptophan
  • L-5-Hydroxytryptophan
  • L-5-Hydroxytryptophan
  • L-5-Hydroxytryptophan
  • L-5-Hydroxytryptophan
  • L-5-Hydroxytryptophan

L-5-Hydroxytryptophan NEW

Price Get Latest Price
Package 25KG
Min. Order: 1KG
Supply Ability: 50000KG/month
Update Time: 2023-08-29

Product Details

Product Name: L-5-Hydroxytryptophan CAS No.: 4350-09-8
EC-No.: 224-411-1 Min. Order: 1KG
Purity: 99% Supply Ability: 50000KG/month
Release date: 2023/08/29

CAS:4350-09-8
MF:C11H12N2O3
MW:220.22
EINECS:224-411-1
Product Categories:Amino Acids;Biochemistry;Biological-modified Amino Acids;Indoles;Tryptophans;Natural Plant Extract;Pharmaceutical Raw Materials;Indoles and derivatives;Tryptophan [Trp, W];Amino acidsPeptide Synthesis;Biochemicals Found in Plants;Nutrition Research;natural product;Inhibitors;Tryptophan Derivatives;Unnatural Amino Acid Derivatives;Amines;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals;Amines, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;amino;Other APIs;4350-09-8
Mol File:4350-09-8.mol
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L-5-Hydroxytryptophan Chemical Properties
Melting point 270 °C (dec.) (lit.)
alpha -32.5 º (c=1,H2O on dry basis)
Boiling point 361.16°C (rough estimate)
density 0.902 g/mL at 25 °C (lit.)
refractive index n20/D 1.4850(lit.)
Fp 175 °F
storage temp. 2-8°C
solubility H2O: 10 mg/mL
pka2.22±0.10(Predicted)
form solid
color white
optical activity[α]22/D 30°, c = 1 in H2O
Water Solubility Slightly soluble
Merck 14,4847
BRN 88200
LogP-0.140 (est)
CAS DataBase Reference4350-09-8(CAS DataBase Reference)
EPA Substance Registry SystemL-5-Hydroxytryptophan (4350-09-8)
L-5-Hydroxytryptophan Usage And Synthesis
Chemical Propertieswhite to pale grey powder
UsesA labelled metabolite of Tryptophan
Uses5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan
Uses5-Hydroxy-L-tryptophan has been used:
  • to inject experimental mice for serotonin detection

  • as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices

  • as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis


DefinitionChEBI: 5-hydroxy-L-tryptophan is the L-enantiomer of 5-hydroxytryptophan. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is a 5-hydroxytryptophan, a hydroxy-L-tryptophan and a non-proteinogenic L-alpha-amino acid. It is an enantiomer of a 5-hydroxy-D-tryptophan. It is a tautomer of a 5-hydroxy-L-tryptophan zwitterion.
General DescriptionColorless to pale pink crystals.
Air & Water ReactionsL-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .
Reactivity ProfileL-5-Hydroxytryptophan reacts with bases. .
Fire HazardFlash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible.
Biochem/physiol ActionsHydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.
Purification MethodsLikely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]

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Packing &shipping&Payment

Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Quantity(Kilograms)1 - 10000>10000
Est. Time(days)5To be negotiated

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Article illustrationCompany information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.

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