Product Details
| Product Name: L-5-Methyltetrahydrofolate Calcium | CAS No.: 151533-22-1 |
| Min. Order: 1ton | Purity: 99% |
| Supply Ability: 1000T/M | Release date: 2025/11/04 |
1. Product Identification
Synonyms:
L-5-MTHF Calcium; (6S)-5-Methyltetrahydrofolic acid, calcium salt; Levomefolate calciumChemical Formula: C??H??CaN?O?
Molecular Weight: ~497.5 g/mol
CAS Number: 151533-22-1
Appearance: Off-white to light yellow powder
Odor: Odorless or faint characteristic odor
2. Grades Available
Industrial Grade: Suitable for synthesis, intermediates, and non-ingestible applications.
Food Grade / Nutraceutical Grade: Complies with relevant food and dietary supplement standards (USP/EP/JP/ChP where applicable).
3. Specifications
| Parameter | Food Grade | Industrial Grade |
|---|---|---|
| Appearance | Off-white to light yellow crystalline powder | Off-white to light yellow powder |
| Assay (HPLC, L-5 isomer) | ≥ 98.0% | ≥ 95.0% |
| Identity (IR, HPLC) | Conforms | Conforms |
| Water Content (Karl Fischer) | ≤ 8.0% | ≤ 10.0% |
| Residual Solvents | Meets ICH Q3C guidelines | Controlled but may not meet pharm. limits |
| Heavy Metals (Pb, As, Cd, Hg) | ≤ 10 ppm (individually ≤ 1 ppm typical) | ≤ 20 ppm total |
| Residual Calcium | 6.0–8.0% | 6.0–8.5% |
| Specific Rotation | +18.0° to +23.0° (20°C) | +16.0° to +24.0° |
| Particle Size (D90) | ≤ 100 μm (customizable) | ≤ 200 μm |
| Microbiological Limits | Total Plate Count ≤ 1000 cfu/g; Yeast & Mold ≤ 100 cfu/g; E. coli / Salmonella: Absent | Not controlled for pathogens |
4. Typical Applications
Food Grade:
Dietary supplements (capsules, tablets, softgels, powders)
Fortification of functional foods & beverages
Pharmaceutical formulations (e.g., prenatal vitamins, cardiovascular health)
Industrial Grade:
Raw material for synthesis of intermediates
Non-nutritional biochemical and laboratory applications
5. Stability & Storage
Stability: Sensitive to light, oxygen, and heat. Food-grade material stabilized with protective agents (ascorbic acid, antioxidants).
Storage Conditions:
Store in a cool, dry place (2–8 °C recommended for long-term stability).
Protect from light and moisture.
Use nitrogen-purged packaging for enhanced shelf-life.
Shelf Life:
Food Grade: 24 months unopened in original packaging.
Industrial Grade: 12–18 months depending on storage conditions.
6. Packaging
Food Grade: 1 kg, 5 kg, or 10 kg vacuum-sealed aluminum foil bags, with secondary packaging in fiber drums.
Industrial Grade: 1–25 kg bags/drums, lined with PE inner bags.
7. Regulatory Information
Food Grade:
USP / EP / JP / ChP monograph compliance (where applicable).
GRAS-notified as a source of folate.
EU Novel Food approval (EFSA).
Approved for use in dietary supplements in USA, EU, and several Asian markets.
Industrial Grade: For technical use only. Not intended for human or animal consumption.
8. Safety & Handling
Hazard Identification: Not classified as hazardous under GHS when used in normal handling.
Precautions: Avoid inhalation of dust; use protective equipment.
First Aid:
Inhalation: Move to fresh air.
Skin Contact: Wash with soap and water.
Eye Contact: Rinse with water.
Spill & Disposal: Collect spillage, avoid dust formation, dispose according to local regulations.
Company Profile Introduction
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- Since: 2025-04-07
- Address: C-309, No. 12 Yuzhou S. Rd, Haizhou, Lianyungang, Jiangsu, China

China