Liothyronine sodium NEW
| Price | $8 | $6 | $2 |
| Package | 1kg | 100kg | 1000kg |
| Min. Order: | 1kg |
| Supply Ability: | g-kg-tons, free sample is available |
| Update Time: | 2024-04-24 |
Product Details
| Product Name: Liothyronine sodium | CAS No.: 55-06-1 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: g-kg-tons, free sample is available | Release date: 2024/04/24 |
| Lead time: In stock | Packaging: bottle/drum/bucket/IBC, as request. |
| Delivery: By sea, by air, by express | Origin: Manufacturer |
| Contact person: Jessica |
1. Product information
| Name | liothyronine sodium |
|---|---|
| Synonym | More Synonyms |
| Description | 3,3',5-Triiodo-L-thyronine sodium is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity. |
|---|---|
| Related Catalog | Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Cancer Research Areas >> Endocrinology |
| Target | TRβ1[1][2] |
| In Vitro | 3,3',5-Triiodo-L-thyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. 3,3',5-Triiodo-L-thyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. 3,3',5-Triiodo-L-thyronine promotes growth, induces differentiation and regualtes metabolic effects[2]. |
| Cell Assay | Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of 3,3',5-Triiodo-L-thyronine (T3) on the growth of cells, cells are plated at a density of 3 × 104 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1]. |
| References | [1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. |
| Boiling Point | 563.5ºC at 760 mmHg |
|---|---|
| Melting Point | 205 °C (dec.)(lit.) |
| Molecular Formula | C15H11I3NNaO4 |
| Molecular Weight | 672.955 |
| Flash Point | 294.6ºC |
| Exact Mass | 672.771973 |
| PSA | 95.61000 |
| LogP | 3.31830 |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
For more details, pls contact us freely.
Mob: 86 17630978909
WhatsApp/Skype/Wechat/LINE: 86 17630978909
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- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro