Liranaftate NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-08-01 |
Product Details
| Product Name: Liranaftate | CAS No.: 88678-31-3 |
| EC-No.: 000-000-0 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 50000KG/month |
| Release date: 2023/08/01 |
| CAS: | 88678-31-3 |
| MF: | C18H20N2O2S |
| MW: | 328.43 |
| EINECS: | 000-000-0 |
| Product Categories: | API;Liranaftate;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;88678-31-3 |
| Mol File: | 88678-31-3.mol |
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| Liranaftate Chemical Properties |
| Melting point | 98.5-99.5°C |
| Boiling point | 462.5±55.0 °C(Predicted) |
| density | 1.240±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 1.24±0.10(Predicted) |
| form | Solid |
| color | Off-White |
| Merck | 14,5515 |
| Uses | Broad-spectrum antifungal |
| Description | Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6，7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed. |
| Chemical Properties | White Crystalline Solid |
| Originator | Tosoh (Japan) |
| Uses | A squalene epoxidase inhibitor. Used as an antifungal. |
| Definition | ChEBI: Liranaftate is a member of tetralins. |
| Brand name | Zefnart |
Packing &shipping&Payment
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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China- Since: 2017-12-08
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