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Postion:Product Catalog >API>Antineoplastic agents>Tinib Antineoplastic drugs>Neratinib (HKI-272)
Neratinib (HKI-272)
  • Neratinib (HKI-272)

Neratinib (HKI-272) NEW

Price Get Latest Price
Package 1g
Min. Order: 1g
Supply Ability: 1KG
Update Time: 2024-03-12

Product Details

Product Name: Neratinib (HKI-272) CAS No.: 698387-09-6
Min. Order: 1g Purity: 98% HPLC
Supply Ability: 1KG Release date: 2024/03/12

Neratinib effect

Neratinib is a kinase inhibitor that binds irreversibly to epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and HER4. In vitro, neratinib decreased EGFR and HER2 autophosphorylation, downstream MAPK and AKT signaling pathways, and showed antitumor activity in EGFR and/or HER2 expressing cancer cell lines. Neratinib human metabolites M3, M6, M7 and M11 inhibit the activity of EGFR, HER2 and HER4 in vitro. In vivo, oral administration of neratinib inhibited tumor growth in mouse xenograft models with tumor cell lines expressing HER2 and EGFR.



Company Profile Introduction

Shandong Perfect Biotechnology Co.Ltd founded in 2014, the company is a supplier and service provider of pharmaceutical and chemical raw materials and animal husbandry and animal health industries. The company is located in Jinan, a beautiful spring city, where the transportation is developed, the logistics is convenient, and the industrial supporting resources are abundant, which provides a stable foundation for the promotion of the company's products. In 2018, the company initiated the establishment of Shandong Qinshi Biotechnology Co., Ltd. to serve domestic veterinary drug preparation companies, and Qinshi successfully passed the national veterinary drug GSP certification on September 10, 2018. In 2020, the company passed the ISO quality management system certification. As a result, the company has formed a pattern in which Jihao Company exports pharmaceutical and chemical raw materials and intermediates, and Qinshi Company serves domestic animal protection enterprises as veterinary raw materials. In this way, it can be more stable and standardized to meet the needs of different customers at home and abroad. At present, the company cooperates closely with several university research institutes and high-tech pharmaceutical industry companies, strictly controls each link from product research and development, production, sales, and dares to innovate, and continuously improves product quality and competitive advantages to promote the company's benign and stable development. We continue to develop superior varieties with our partners, and provide customers with products that meet customer requirements in accordance with CP, JP, BP, USP, EP and other standards, making our products and services a close and stable partner for customers. The company pays equal attention to the development of both international and domestic markets, and a complete sales team can serve its partners wholeheartedly. We provide products and services to our customer

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