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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Endocrinology & Hormones>RAAS inhibitors>Sacubitril Valsartan sodium
Sacubitril Valsartan sodium
  • Sacubitril Valsartan sodium
  • Sacubitril Valsartan sodium
  • Sacubitril Valsartan sodium
  • Sacubitril Valsartan sodium
  • Sacubitril Valsartan sodium

Sacubitril Valsartan sodium NEW

Price Get Latest Price
Package 1Kg/Bag 25Kg/Bag 100Kg/Bag
Min. Order: 1Kg/Bag
Supply Ability: 20 tons
Update Time: 2024-04-22

Product Details

Product Name: Sacubitril Valsartan sodium CAS No.: 936623-90-4
EC-No.: 000-000-0 Min. Order: 1Kg/Bag
Purity: 99% up, High Density Supply Ability: 20 tons
Release date: 2024/04/22

Product Information

roduct NameFactory Supply Valsartan Sacubitril Powder CAS 936623-90-4 Valsartan Sacubitril  For Pharmaceutical Intermediate
Appearancepowder
cas936623-90-4
Assay99%
KeywordsValsartan Sacubitril;Valsartan Sacubitril Powder;Valsartan Sacubitril CAS 936623-90-4
Shelf Life24 months when properly stored
StorageKeep in a cool, dry, dark location


Article illustrationWhat is Valsartan Sacubitril?

LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan (Item No. 14178) and AHU377 (Item No. 21473), a prodrug of LBQ657 (Item No. 19829), which is an inhibitor of the zinc metallopeptidase neprilysin., LCZ696 (2-60 mg/kg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension. Formulations containing LCZ696 are under clinical investigation for the treatment of mild to moderate hypertension and chronic heart failure.


Usage  


Function of Valsartan Sacubitril
 

LCZ696, a first-in-class inhibitor of dualacting angiotensin-2 type-I receptor and neprilysin inhibitors, was developed as a molecule composed of molecular moieties of valsartan and neprilysin inhibitor prodrug AHU377 in a 1:1 ratio. Several phase 2 randomised clinical trials have been done or are underway in patients with hypertension. In a proof-of-concept randomised trial, LCZ696 was compared with valsartan in 1328 patients with mild-to-moderate hypertension, and provided fully additive reduction of blood pressure. No cases of angio-oedema were reported in the 8 week treatment period. This tolerance should be confirmed, particularly in black patients, for whom omapatrilat resulted in a higher occurrence of angio-oedema than in white patients. Indeed, in the proof-of-concept trial only about 8% of patients were black.


Company Information

Article illustration


Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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