Triptorelin/GnRH NEW

CAS No.:57773-63-4

Formula: C₆₄H₈₂N₁₈O₁₃

Key Specification:

Appearance:  White powder
Purity (HPLC) ≥99.0%

Package:

Vacuum packaging in aluminum foil bags, plastic bottles or transparent bags. 10mg, 50mg, 100mg, 1g, 10g, 50g per package, with ice packs. Or customized according to your requirements.

Suppliers of Triptorelin, Triptorelin Suppliers, Direct Sales by Triptorelin Merchants, Spot Supply of Triptorelin, National Supply Quotation of Triptorelin, Wholesale Quotation of Triptorelin

Triptorelin is a GnRH agonist, and its use must strictly follow clinical specifications. The treatment plan should be adjusted according to the indications and the individual conditions of patients. The following are the key precautions:

1. Pre-medication Evaluation and Screening

- Contraindication Screening

- It is contraindicated for those who are allergic to triptorelin or GnRH drugs;

- It is contraindicated for pregnant women and lactating women;

- It is contraindicated for patients who have undergone non-hormone-dependent certain resection;

- Patients with severe liver problems need to be cautious, as drug metabolism may be affected, and liver enzymes and creatinine levels need to be monitored.

- Baseline Status Assessment

- Before use, sex** levels (such as testosterone, estradiol), liver and kidney functions, blood routine, etc. need to be tested as the baseline for monitoring;

- Some patients need to assess the staging and condition to avoid the initial "flare-up effect" from aggravating pain or urinary tract obstruction;

- Female patients need to rule out pregnancy (which can be detected by urine HCG), and non-hormonal contraceptive methods should be used during the period.

2. Management of Adverse Reactions During Medication

- Response to Initial "Flare-up Effect"

- Transient increase in sex hormones may occur 1-2 weeks after medication, causing related abnormal reactions; female patients may experience aggravated pelvic discomfort. At this time, it is necessary to follow the doctor's advice to combine anti-androgen drugs (such as flutamide) or non-steroidal drugs for relief, and avoid stopping the drug by yourself.

- Monitoring of Long-term "Low Sex Hormone State"

- Common adverse reactions include hot flashes, etc., which are mostly temporary and can be relieved by lifestyle adjustments (such as maintaining a cool environment and regular work and rest). When severe, symptomatic treatment is required;

- Female patients may experience menstrual disorders, etc., and can use local estrogen ointment under the doctor's guidance (low dose to avoid affecting );

- Long-term medication (especially for more than 6 months) may lead to decreased bone density. It is necessary to monitor bone density regularly, and at the same time supplement calcium and vitamin D. Post- women or elderly men need to be more vigilant against risks.

- Other Rare but Alert Reactions

- A small number of patients may experience redness, swelling or rash at the injection site, which are usually local reactions and can be relieved by hot compress. If an allergic reaction occurs, stop the drug immediately and seek medical attention;

- In rare cases, it may cause mood swings, especially in female patients. It is necessary to pay attention to the psychological state and combine psychological intervention if necessary.

3. Medication Precautions for Special Populations

- Pediatric Patients

- It is necessary to regularly monitor indicators (height, bone age, sex** level) to avoid excessive retardation;

- Long-term medication may affect the rhythm of puberty development. It is necessary to evaluate the progress of bone age every 6-12 months and adjust the medication cycle.

- Elderly Patients

- Strictly follow the dosage form requirements

- Short-acting preparations (such as daily injection) need to be administered at a fixed time to avoid missing doses; long-acting sustained-release preparations (such as 1-month or 3-month formulations) need to be injected deeply into muscles (buttocks or deltoid muscles) to ensure slow release of the drug. Avoid rubbing the injection site after injection.

4. Principles of Dosage Adjustment

- The dosage needs to be adjusted according to the indications

5. Requirements for Drug Discontinuation and Follow-up 

- Monitoring

- During the period, regular re-examinations and imaging examinations are required to evaluate the drug response.

- Observation of Recovery After Drug Discontinuation

- After stopping the drug, the sex** level and pituitary function gradually recover, and follow-up is required until the indicators are stable (usually 3-6 months);

- In assisted reproduction, after stopping the drug, it is necessary to monitor the recovery of ovulation to avoid premature pregnancy affecting the environment.

- Do Not Discontinue or Adjust the Dosage Without Authorization

- Sudden discontinuation of the drug may lead to a rebound increase in sex hormones and aggravate the condition. It is necessary to gradually adjust the plan under the guidance of a doctor.

6. Precautions for Special Scenarios

- Before and after surgery: If surgical operation is needed, it is necessary to inform the doctor of the medication history in advance, because the low testosterone state may affect drug metabolism;

- Driving and operating machinery: Some patients may experience dizziness, etc. During medication, attention should be paid to safety and avoid engaging in dangerous activities.

In conclusion, the use of triptorelin must be under the guidance of a specialist doctor. The risks and benefits should be dynamically evaluated in combination with the individual conditions of patients. Through standardized monitoring and management of adverse reactions, the effect can be maximized and potential hazards can be reduced.