ChemicalBook >>Calcitriol>>1alpha,25-Dihydroxycholecalciferol(32222-06-3)

1alpha,25-Dihydroxycholecalciferol(32222-06-3)

1alpha,25-Dihydroxycholecalciferol(32222-06-3)
Product IdentificationBack to Contents
【Product Name】

1alpha,25-Dihydroxycholecalciferol
【Synonyms】

1,25-Dihydroxycholecalciferol
1,25-Dihydroxyvitamin D3
9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1a,3b,5Z,7E)-
Calcitriol
Rocaltrol
Topitriol
【CAS】

32222-06-3
【Formula】

C27H44O3
【Molecular Weight】

416.64
【EINECS】

250-963-8
【RTECS】

FZ4645000
【RTECS Class】

Drug; Mutagen; Reproductive Effector
【Merck】

12,1681
【Beilstein/Gmelin】

2065599
Physical and Chemical PropertiesBack to Contents
【Appearance】

Colorless, crystalline solid.
【Solubility in water】

Insoluble
【Melting Point】

95 - 99
【pKa/pKb】

13.98 (pKa)
【Usage】

Medication.
First Aid MeasuresBack to Contents
【Ingestion】

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
【Inhalation】

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
【Skin】

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
【Eyes】

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
Handling and StorageBack to Contents
【Storage】

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
【Handling】

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
【Respirators】

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
【Exposure Effects】

Symptoms are similar to hypercalcemia: anorexia, fatigue, headache, itching, and weakness. Polyneuropathy has been reported after acute intoxication. In humans, aortic stenosis was associated with high doses of vitamin D in pregnancy. However, conflicting results have been observed. In animal studies, toxic effects including fetotoxicity, spontaneous abortion and specific developmental abnormalities were observed.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability and ReactivityBack to Contents
【Stability】

No data.
【Incompatibilities】

Strong oxidizing agents.
Hazards IdentificationBack to Contents
【Ingestion】

Nausea, vomiting, and diarrhea may be seen.
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