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Calcitriol Suppliers list
Tel: +31 318 545 767
Products Intro: Product Name:Calcitriol, 1α,25-dihydroxycholecalciferol, 1α,25-dihydroxyvitamin D3
Purity:EP / USP / CEP / IP Package:Flexible packaging Remarks:HS code is 29362900, regular product and working standard (ARS) available
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Products Intro: Product Name:Calcitriol
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Calcitriol
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:32222-06-3
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Products Intro: Product Name:1alpha,25-Dihydroxycholecalciferol
Calcitriol Basic information
Introduction References
Product Name:Calcitriol
Synonyms:(5z,7e)-9,10-secocholesta-5,7,10(19)-triene-1-alpha,3-beta,25-triol;1,25-dhcc;1,25-dihydroxycholecalciferol;1,25-dihydroxyvitamind;1a,25-dihydroxy-cholecalcifero;1-alpha,25-dihydroxy-cholecalcifero;Vitamin D3, 1a,25-Dihydroxy-;CALCITRIOL USP
Product Categories:Miscellaneous Biochemicals;Vitamin D3 analogs;API;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors;Isolabel;reagent;standard substance
Mol File:32222-06-3.mol
Calcitriol Structure
Calcitriol Chemical Properties
Melting point 119-1210C
alpha D25 +48° (methanol)
Boiling point 474.91°C (rough estimate)
density 1.0362 (rough estimate)
refractive index 1.4700 (estimate)
Fp 14 °C
storage temp. 2-8°C
solubility Do you have solubility information on this product that you would like to share
form Solid
Merck 14,1644
BRN 7559394
Stability:Air and Light Sensitive
CAS DataBase Reference32222-06-3(CAS DataBase Reference)
Safety Information
Hazard Codes T+,Xn,F
Risk Statements 26/27/28-63-36/37/38-20/21/22-11
Safety Statements 36/37/39-45-36-26-16-7
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS FZ4645000
HazardClass 6.1(a)
PackingGroup I
HS Code 29061900
Hazardous Substances Data32222-06-3(Hazardous Substances Data)
MSDS Information
1alpha,25-Dihydroxycholecalciferol English
SigmaAldrich English
Calcitriol Usage And Synthesis
IntroductionCalcitriol (1,25-dihydroxylcholecaldiferol) is a steroid hormone with three hydroxyl groups, which is an active metabolite and the most effective form of vitamin D. It is produced primarily in the kidney when the blood calcium level and parathyroid hormone are low. Calcitriol promotes the calcium and phosphorus absorption in the intestine, reabsorption in the kidneys. Along with parathyroid hormone, it regulates bone growth for building and keeping strong bones. Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands are not working normally, to treat secondary hyperparathyroidism and metabolic bone disease in people with kidney disease. Calcitriol may also be chemopreventive for colon and prostate cancers as it induces cell cycle arrest, cell differentiation, and apoptosis.
DescriptionCalcitriol is the active form of vitamin D and is also a kind of hormones in the body. It plays an important role in the regulation of calcium and phosphorus concentration. It can increase the blood calcium level by increasing the intestinal absorption of calcium and can also increase the release of the bone calcium release for increasing the blood calcium levels. This study was first conducted and reported by Michael F. Holick in 1971. The basic principle of action model of calcitriol in many cases is through binding with the vitamin D receptor (the VDR), e.g., the ligand-receptor complex forming between calcitriol and its receptor in the intestinal epithelial cells cytoplasm can be transferred to the nucleus for being as the transcriptional factor in promoting the expression of calcium-binding protein. The increased level of calcium-binding proteins can help the cell to actively transport of more calcium ions, thereby increasing the calcium absorption level. Calcium absorption while maintaining electrical neutrality also requires transporting anions, mainly the absorption of inorganic phosphate ions, so calcitriol also promote the absorption of phosphorus.
Clinically, this drug can be used in the treatment of hypocalcemia, hypoparathyroidism (adult), osteomalacia, rickets (infants), chronic kidney disease, renal osteodystrophy, osteoporosis, as well as the prevention of glucocorticoid induced osteoporosis.
Calcitriol-dimensional molecular structure
Calcitriol-dimensional molecular structure
The above information is edited by the chemicalbook of Dai Xiongfeng.
Chemical PropertiesWhite Crystalline Powder
UsesCalcium regulator, anti-psoriatic
UsesVitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure;
UsesThe biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic
DefinitionChEBI: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the li er to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
UsesCalcitriol (1α,25-dihydroxy Vitamin D3) is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.[Cayman Chemical]
Brand nameCalcijex (Abbott); Rocaltrol (Roche.
Biological ActivityActive metabolite of vitamin D 3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca 2+ absorption and regulates bone Ca 2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
Calcitriol Preparation Products And Raw materials
Tag:Calcitriol(32222-06-3) Related Product Information
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