Captopril;A333;甲巯丙脯酸

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抑制剂描述：

产品名称：Captopril

产品别名：卡托普利;甲巯丙脯酸

英文别名：SA333

靶点：Angiotensin-converting Enzyme (ACE)

CAS：62571-86-2

纯度：>98%

外观：白色或类白色结晶性粉末

保存方法：-20°C

描述：

Captopril是一种血管紧张素转换酶（ACE）抑制剂，IC50为6 nM。

溶解性：DMSO ：21.7 mg/mL (100 mM)
Water ：21.7 mg/mL (100 mM)

体外研究：

Captopril (SQ-14534) has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril (SQ-14534) has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes. An equimolar ratio of the cis and trans states of Captopril (SQ-14534) exists in solution and that the enzyme selects only the trans state of the inhibitor that presents architectural and stereoelectronic complementarity with its substrate binding groove.

体内研究：

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