Toxicity of Dinotefuran

Dinotefuran is an active ingredient of insecticides ,it is used for termite control for homes, flea and tick control for pets, household insecticides and many other purposes. In addition to insecticidal activity against a wide range of pests, it has many features such as excellent systemic properties and an sucking inhibition on stink bugs.

Properties

Technical dinotefuran is an odorless white crystalline solid. It has a solubility of 39.83 g/L in water, and is highly soluble in dichloromethane, acetone, methanol, and ethyl acetate. Technical dinotefuran has a melting point of 107.5℃, and a log Pow of -0.549 at 25℃. It is nonflammable, is not explosive to thermal, shock and frictional tests, and has a vapor pressure of <1.7 x 10-6 Pa at 25℃.

Use

Dinotefuran is used in veterinary medicine as a flea and tick preventive for dogs and as a flea preventive for cats. It is used in combination with pyriproxifen or permethrin.

Toxicity

Acute Toxicity 

Technical dinotefuran has low acute toxicity by the oral (toxicity category IV), dermal (toxicity category IV), and inhalation (toxicity category IV) routes. It is not a dermal sensitizer, causes a low level of skin irritation (toxicity category IV) and moderate eye irritation (toxicity category II) (Table I).

Subchronic and Chronic Toxicity 

The main target tissues are the nervous system and the immune system, with effects seen in several species. Nervous system toxicity is manifested as clinical signs and decreased motor activity seen after acute dosing (in both rats and rabbits) and increased motor activity seen after repeated dosing; these findings are consistent with effects on the nicotinic cholinergic nervous system.