What is Lysergol?

Lysergol is an alkaloid of the ergoline family that occurs as a minor constituent in some species of fungi (most within Claviceps), and in the morning glory family of plants (Convolvulaceae), including the hallucinogenic seeds of Rivea corymbosa (ololiuhqui), Argyreia nervosa (Hawaiian baby woodrose) and Ipomoea violacea. Lysergol is not a controlled substance in the USA. Its possession and sale is also legal under the U.S. Federal Analog Act because it does not have a known pharmacological action or a precursor relationship to LSD, which is a controlled substance. However, lysergol is an intermediate in the manufacture of some ergoloid medicines (e.g., nicergoline).

Synthesise

Lysergol can be synthesised using a tandem reaction to construct the piperidine skeleton and a rhodium-catalyzed [3 + 2] annulation in the late-stage indole formation.

Uses

Lysergol has been used as a hypotensive, psychotropic analgesic, and uterus- and intestine-stimulating drug. Lysergol is a clavinet alkaloid isolated from seeds of Ipomoea muricata and is a bioenhancer for the drugs and nutrients and has antibacterial activity.

Lysergol has been used as hypotensive, psychotropic analgesic and uterus and intestine stimulating drug.

Recently invented the novel bio enhancing potential of lysergol, which acts as bioavailability facilitator for antibiotics and helps in transferring the antibiotics across the membrane for better efficacy on the target site.

Starting material for the synthesis of modern anti Parkinson drug “Cabergoline”.

As an main intermediate in the manufacture of ergoloid medicines (e.g., Nicergoline).

Source

Ipomoea muricata synonyms I. turbinate, Calonyction muricata belongs to the family of the Convolvulaceae. It is a creeper and widely grows in all places. The plant is commonly known as morning glory. Flowers are purple or white up to 8 cm diameter. Fruits are pendulum shape capsules. Seeds are commonly known as “Kaladana” in trade and are being used as purgative in India and Pakistan.