Терфенадин
Терфенадин атрибут
| Температура плавления: |
145-152 °C |
| Температура кипения: |
572.76°C (rough estimate) |
| плотность: |
1.0488 (rough estimate) |
| показатель преломления: |
1.6310 (estimate) |
| температура хранения: |
2-8°C |
| растворимость: |
хлороформ: растворим 250 мг плюс 5 мл растворителя, от прозрачного до слегка мутного, от бесцветного до бледно-желтого |
| пка: |
pKa 9.21(H2O
t = 25
I = 0.025) (Uncertain) |
| форма: |
Solid |
| цвет: |
От белого до не совсем белого |
| Растворимость в воде: |
0,001 г/100 мл (30°С) |
| ИнЧИКей: |
GUGOEEXESWIERI-UHFFFAOYSA-N |
| SMILES: |
C(O)(C1C=CC=CC=1)(C1=CC=CC=C1)C1CCN(CCCC(O)C2C=CC(C(C)(C)C)=CC=2)CC1 |
| Справочник по базе данных CAS: |
50679-08-8(CAS DataBase Reference) |
| FDA UNII: |
7BA5G9Y06Q |
| Код УВД: |
R06AX12 |
| Справочник по химии NIST: |
Seldane(50679-08-8) |
| UNSPSC Code: |
41116107 |
| NACRES: |
NA.77 |
Терфенадин химические свойства, назначение, производство
Химические свойства
White Solid
Использование
Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats.
Всемирная организация здравоохранения(ВОЗ)
The first clinically interesting histamine H-receptor1 antagonists
were introduced in the late 1940s and early 1950s. Several H-antihistaminics have
a similar cardiac effect to that seen with astemizole1 and terfenadine. Serious
cardiovascular adverse reactions have been reported when used concomitantly
with imidazole antifungals and macrolide antibiotics. See also under astemizole.
Биологическая активность
Histamine H 1 receptor antagonist. Also blocks hERG and K ATP channels (IC 50 values are 204 nM and 1.2 μ M respectively). Inhibits the delayed rectifier K + current (I Kr ) in guinea pig ventricular myocytes (IC 50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo .
Фармаколо?гия
Terfenadine not only differs from the other antihistamine drugs in its chemical structure,
but also in that its action begins within 1–2 h and last approximately 12 h, reaching its
peak of action in 3–4 h.
Терфенадин препаратная продукция и сырье
сырьё
препарат
Терфенадин поставщик
Global( 213)Suppliers
50679-08-8(Терфенадин)подобный поиск: