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Scientific Reports
Scientific Reports
IF:3.8
CiteScore:7.5
Articles:19567
We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections.
Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021).
•Engineering
Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live.
•Physical sciences
Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics.
•Earth and environmental sciences
Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems.
•Biological sciences
Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants.
•Health sciences
The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
RO8191, a new compound for initiating embryo implantation in mice
Published: 9 September 2025
DOI: 10.1038/s41598-025-18471-3
Junlan Shu, Jumpei Terakawa, Sota Takikawa, Satoko Osuka, Ayako Muraoka, Jiali Ruan, Atsuo Iida, Junya Ito, Eiichi Hondo
Junlan Shu, Jumpei Terakawa, Sota Takikawa, Satoko Osuka, Ayako Muraoka, Jiali Ruan, Atsuo Iida, Junya Ito, Eiichi Hondo
MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response
Published: 8 August 2025
DOI: 10.1038/s41598-025-14527-6
Zhao-Feng Wen, Qi-Tang Huang, Yang-Yang Wang, Feng-Ya Nan, Zhi-Min Zhai, Yan-Li Li
Zhao-Feng Wen, Qi-Tang Huang, Yang-Yang Wang, Feng-Ya Nan, Zhi-Min Zhai, Yan-Li Li
High-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition
Published: 1 August 2025
DOI: 10.1038/s41598-025-08384-6
Chiao-Hsu Ke, Mao-En Huang, Hsin-Yi Wu, Chao-Wu Yu, Shuei-Liong Lin, Shau-Ping Lin, Shu-Han Yu, Chih-Hung Huang, Chen-Si Lin
Chiao-Hsu Ke, Mao-En Huang, Hsin-Yi Wu, Chao-Wu Yu, Shuei-Liong Lin, Shau-Ping Lin, Shu-Han Yu, Chih-Hung Huang, Chen-Si Lin
An in vivo rat model for comparing selective blockade between sensory and motor nerve conduction
Published: 20 July 2025
DOI: 10.1038/s41598-025-12201-5
Yi Teng, Xian Zou, Jin Liu, Xiangyu Hu, Cheng Zhou, Mengchan Ou
Yi Teng, Xian Zou, Jin Liu, Xiangyu Hu, Cheng Zhou, Mengchan Ou
Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma
Published: 19 July 2025
DOI: 10.1038/s41598-025-12192-3
Wei Chang, Biao Zhang, Shujun Yang, Xingxing Zhang, Lili Zhang, Su Zhang, Jianzhong Lu, Wei Wang, Panfeng Shang, Zhongjin Yue
Wei Chang, Biao Zhang, Shujun Yang, Xingxing Zhang, Lili Zhang, Su Zhang, Jianzhong Lu, Wei Wang, Panfeng Shang, Zhongjin Yue
Construction and validation of a cell based reporter assay for identifying inhibitors of SARS coronavirus 2 RNA dependent RNA polymerase activity
Published: 26 May 2025
DOI: 10.1038/s41598-025-03813-y
Eunjeong Kang, Haelim Yoon, Junho Lee, JinAh Lee, Seungtaek Kim, Inseong Jo, Soo Bong Han, Dae Gwin Jeong, Sayeon Cho
Eunjeong Kang, Haelim Yoon, Junho Lee, JinAh Lee, Seungtaek Kim, Inseong Jo, Soo Bong Han, Dae Gwin Jeong, Sayeon Cho
Design and bioactivity evaluation of a novel autotaxin inhibitor with anti-hepatic fibrosis effects
Published: 1 April 2025
DOI: 10.1038/s41598-025-95464-2
Yuzheng Liu, Dan Luo, Hongwen Leng, Chaolun Gu, Qingrong Ding, Lin Zhao, Xinxin Chao, Hanxia Wang, Yueteng He, Silu Zhu, Guanhua Ai, Weijie Peng
Yuzheng Liu, Dan Luo, Hongwen Leng, Chaolun Gu, Qingrong Ding, Lin Zhao, Xinxin Chao, Hanxia Wang, Yueteng He, Silu Zhu, Guanhua Ai, Weijie Peng
Glaucocalyxin A alleviates ulcerative colitis by inhibiting PI3K/AKT/mTOR signaling
Published: 24 February 2025
DOI: 10.1038/s41598-025-91358-5
Tongtong Zhou, Yujing Ye, Weijie Chen, Yanyan Wang, Lulu Ding, Yicun Liu, Leilei Luo, Lixian Wei, Jian Chen, Zhaolian Bian
Tongtong Zhou, Yujing Ye, Weijie Chen, Yanyan Wang, Lulu Ding, Yicun Liu, Leilei Luo, Lixian Wei, Jian Chen, Zhaolian Bian
ERS regulates endometrial epithelial cell autophagy through XBP1s-mediated activation of the PI3K/AKT pathway
Published: 18 February 2025
DOI: 10.1038/s41598-024-84461-6
Kangkang Gao, Yiteng Zhao, Mengqi Si, Beibei Zhang, Zongjie Wang, Huatao Chen, Pengfei Lin, Aihua Wang, Yaping Jin
Kangkang Gao, Yiteng Zhao, Mengqi Si, Beibei Zhang, Zongjie Wang, Huatao Chen, Pengfei Lin, Aihua Wang, Yaping Jin
Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression
Published: 6 February 2025
DOI: 10.1038/s41598-025-88670-5
Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu
Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu
DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism
Published: 28 January 2025
DOI: 10.1038/s41598-025-87389-7
Xinrong Wu, Yifan Li, Weiwei Wang, Jiale Xu, Bei Zhao, Wenqi Sun, Dan Ge, Longying Xiong, Xiaotan Dou, Xiaoping Zou, Lei Wang, Min Chen
Xinrong Wu, Yifan Li, Weiwei Wang, Jiale Xu, Bei Zhao, Wenqi Sun, Dan Ge, Longying Xiong, Xiaotan Dou, Xiaoping Zou, Lei Wang, Min Chen
Imaging flow cytometry reveals the mechanism of equine arteritis virus entry and internalization.
Published: 25 January 2025
DOI: 10.1038/s41598-025-87080-x
Agata Kublicka, Daria Lorek, Agata Mikołajczyk-Martinez, Grzegorz Chodaczek, Aleksandra Chwirot, Barbara Bażanów, Anna Karolina Matczuk
Agata Kublicka, Daria Lorek, Agata Mikołajczyk-Martinez, Grzegorz Chodaczek, Aleksandra Chwirot, Barbara Bażanów, Anna Karolina Matczuk
Characterization of a pleomorphic rhabdomyosarcoma cell line
Published: 23 January 2025
DOI: 10.1038/s41598-025-87027-2
Sandra Stickler, Clemens Lang, Maximilian Rieche, Marie-Therese Eggerstorfer, Martin Hohenegger, Maximilian Hochmair, Gerhard Hamilton
Sandra Stickler, Clemens Lang, Maximilian Rieche, Marie-Therese Eggerstorfer, Martin Hohenegger, Maximilian Hochmair, Gerhard Hamilton
A novel approach for target deconvolution from phenotype-based screening using knowledge graph
Published: 18 January 2025
DOI: 10.1038/s41598-025-86166-w
Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun
Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun
Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics
Published: 30 December 2024
DOI: 10.1038/s41598-024-83986-0
Tiago Ribeiro, Mariana Reis, Vitor Vasconcelos, Ralph Urbatzka
Tiago Ribeiro, Mariana Reis, Vitor Vasconcelos, Ralph Urbatzka
The dual role of calnexin on malignant progression and tumor microenvironment in glioma
Published: 28 December 2024
DOI: 10.1038/s41598-024-81192-6
Wenxia Wang, Yinmin Shi, Bo Yan, Yuang Cai, Han Zheng, Yuan Zhang, Liang Wang, Huijuan Wang
Wenxia Wang, Yinmin Shi, Bo Yan, Yuang Cai, Han Zheng, Yuan Zhang, Liang Wang, Huijuan Wang
Clusterin mediates hydroquinone-induced cytotoxic responses in HL-60 differentiated cells
Published: 5 December 2024
DOI: 10.1038/s41598-024-82140-0
Peimao Li, Qirui Gong, Dianpeng Wang, Zhimin Zhang, Wen Zhang
Peimao Li, Qirui Gong, Dianpeng Wang, Zhimin Zhang, Wen Zhang
Nrf2 depletion enhanced curcumin therapy effect in gastric cancer by inducing the excessive accumulation of ROS
Published: 4 December 2024
DOI: 10.1038/s41598-024-81375-1
Yan Wang, Shasha Wang, Chenchen Ma, Weiwei Qi, Jing Lv, Mengqi Zhang, Shibo Wang, Rui Wang, Yangyang Lu, Wensheng Qiu
Yan Wang, Shasha Wang, Chenchen Ma, Weiwei Qi, Jing Lv, Mengqi Zhang, Shibo Wang, Rui Wang, Yangyang Lu, Wensheng Qiu
Hydrophobic modification and durability protection of cotton garment fabric surfaces by graphene oxide/PGMA composite coatings
Published: 4 December 2024
DOI: 10.1038/s41598-024-71736-1
Xiaoya He, Wenhui Zhou
Xiaoya He, Wenhui Zhou
Stereolithography 3D printing gyroid triply periodic minimal surface vitrified bond diamond grinding wheel
Published: 3 December 2024
DOI: 10.1038/s41598-024-81641-2
Zhaoqi Chen, Kehan Li, Ping Han, Yuetang Pan, Guoju Bai, Zijing Xia, Na Xiao, Pengyu Wang
Zhaoqi Chen, Kehan Li, Ping Han, Yuetang Pan, Guoju Bai, Zijing Xia, Na Xiao, Pengyu Wang




