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Scientific Reports

Scientific Reports

IF:3.8 CiteScore:7.5 Articles:19567
We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.

RO8191, a new compound for initiating embryo implantation in mice

Published: 9 September 2025 DOI: 10.1038/s41598-025-18471-3
Junlan Shu, Jumpei Terakawa, Sota Takikawa, Satoko Osuka, Ayako Muraoka, Jiali Ruan, Atsuo Iida, Junya Ito, Eiichi Hondo

MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response

Published: 8 August 2025 DOI: 10.1038/s41598-025-14527-6
Zhao-Feng Wen, Qi-Tang Huang, Yang-Yang Wang, Feng-Ya Nan, Zhi-Min Zhai, Yan-Li Li

High-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition

Published: 1 August 2025 DOI: 10.1038/s41598-025-08384-6
Chiao-Hsu Ke, Mao-En Huang, Hsin-Yi Wu, Chao-Wu Yu, Shuei-Liong Lin, Shau-Ping Lin, Shu-Han Yu, Chih-Hung Huang, Chen-Si Lin

An in vivo rat model for comparing selective blockade between sensory and motor nerve conduction

Published: 20 July 2025 DOI: 10.1038/s41598-025-12201-5
Yi Teng, Xian Zou, Jin Liu, Xiangyu Hu, Cheng Zhou, Mengchan Ou

Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma

Published: 19 July 2025 DOI: 10.1038/s41598-025-12192-3
Wei Chang, Biao Zhang, Shujun Yang, Xingxing Zhang, Lili Zhang, Su Zhang, Jianzhong Lu, Wei Wang, Panfeng Shang, Zhongjin Yue

Construction and validation of a cell based reporter assay for identifying inhibitors of SARS coronavirus 2 RNA dependent RNA polymerase activity

Published: 26 May 2025 DOI: 10.1038/s41598-025-03813-y
Eunjeong Kang, Haelim Yoon, Junho Lee, JinAh Lee, Seungtaek Kim, Inseong Jo, Soo Bong Han, Dae Gwin Jeong, Sayeon Cho

Design and bioactivity evaluation of a novel autotaxin inhibitor with anti-hepatic fibrosis effects

Published: 1 April 2025 DOI: 10.1038/s41598-025-95464-2
Yuzheng Liu, Dan Luo, Hongwen Leng, Chaolun Gu, Qingrong Ding, Lin Zhao, Xinxin Chao, Hanxia Wang, Yueteng He, Silu Zhu, Guanhua Ai, Weijie Peng

Glaucocalyxin A alleviates ulcerative colitis by inhibiting PI3K/AKT/mTOR signaling

Published: 24 February 2025 DOI: 10.1038/s41598-025-91358-5
Tongtong Zhou, Yujing Ye, Weijie Chen, Yanyan Wang, Lulu Ding, Yicun Liu, Leilei Luo, Lixian Wei, Jian Chen, Zhaolian Bian

ERS regulates endometrial epithelial cell autophagy through XBP1s-mediated activation of the PI3K/AKT pathway

Published: 18 February 2025 DOI: 10.1038/s41598-024-84461-6
Kangkang Gao, Yiteng Zhao, Mengqi Si, Beibei Zhang, Zongjie Wang, Huatao Chen, Pengfei Lin, Aihua Wang, Yaping Jin

Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression

Published: 6 February 2025 DOI: 10.1038/s41598-025-88670-5
Juan Du, Ruyun Liu, Lin Ma, Yue Liu, Wei Wei, Ning Liu, Qiuhua Cao, Jianqiang Yu

DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism

Published: 28 January 2025 DOI: 10.1038/s41598-025-87389-7
Xinrong Wu, Yifan Li, Weiwei Wang, Jiale Xu, Bei Zhao, Wenqi Sun, Dan Ge, Longying Xiong, Xiaotan Dou, Xiaoping Zou, Lei Wang, Min Chen

Imaging flow cytometry reveals the mechanism of equine arteritis virus entry and internalization.

Published: 25 January 2025 DOI: 10.1038/s41598-025-87080-x
Agata Kublicka, Daria Lorek, Agata Mikołajczyk-Martinez, Grzegorz Chodaczek, Aleksandra Chwirot, Barbara Bażanów, Anna Karolina Matczuk

Characterization of a pleomorphic rhabdomyosarcoma cell line

Published: 23 January 2025 DOI: 10.1038/s41598-025-87027-2
Sandra Stickler, Clemens Lang, Maximilian Rieche, Marie-Therese Eggerstorfer, Martin Hohenegger, Maximilian Hochmair, Gerhard Hamilton

A novel approach for target deconvolution from phenotype-based screening using knowledge graph

Published: 18 January 2025 DOI: 10.1038/s41598-025-86166-w
Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun

Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics

Published: 30 December 2024 DOI: 10.1038/s41598-024-83986-0
Tiago Ribeiro, Mariana Reis, Vitor Vasconcelos, Ralph Urbatzka

The dual role of calnexin on malignant progression and tumor microenvironment in glioma

Published: 28 December 2024 DOI: 10.1038/s41598-024-81192-6
Wenxia Wang, Yinmin Shi, Bo Yan, Yuang Cai, Han Zheng, Yuan Zhang, Liang Wang, Huijuan Wang

Clusterin mediates hydroquinone-induced cytotoxic responses in HL-60 differentiated cells

Published: 5 December 2024 DOI: 10.1038/s41598-024-82140-0
Peimao Li, Qirui Gong, Dianpeng Wang, Zhimin Zhang, Wen Zhang

Nrf2 depletion enhanced curcumin therapy effect in gastric cancer by inducing the excessive accumulation of ROS

Published: 4 December 2024 DOI: 10.1038/s41598-024-81375-1
Yan Wang, Shasha Wang, Chenchen Ma, Weiwei Qi, Jing Lv, Mengqi Zhang, Shibo Wang, Rui Wang, Yangyang Lu, Wensheng Qiu

Hydrophobic modification and durability protection of cotton garment fabric surfaces by graphene oxide/PGMA composite coatings

Published: 4 December 2024 DOI: 10.1038/s41598-024-71736-1
Xiaoya He, Wenhui Zhou

Stereolithography 3D printing gyroid triply periodic minimal surface vitrified bond diamond grinding wheel

Published: 3 December 2024 DOI: 10.1038/s41598-024-81641-2
Zhaoqi Chen, Kehan Li, Ping Han, Yuetang Pan, Guoju Bai, Zijing Xia, Na Xiao, Pengyu Wang