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Scientific Reports

IF:3.8 CiteScore:7.5 Articles:19567

We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.

IGSF6 is a novel biomarker to evaluate immune infiltration in mismatch repair-proficient colorectal cancer

Published: 21 November 2023 DOI: 10.1038/s41598-023-47739-9
Yu-Ming Rong, Yu-Cheng Xu, Xiao-Chuan Chen, Min-Er Zhong, Ying-Xin Tan, Yu-Fan Liang, Jing-Rong Weng, Jun Liu, Xin-You Wang, Dan-Dong Luo, Yi-Ran Bie, Xi Chen, Jia-Wei Cai, Zhao-Liang Yu, Yi-Feng Zou

A novel pathway of levodopa metabolism by commensal Bifidobacteria

Published: 6 November 2023 DOI: 10.1038/s41598-023-45953-z
M S Cirstea, A Creus-Cuadros, C Lo, A C Yu, A Serapio-Palacios, S Neilson, S Appel-Cresswell, B B Finlay

4-Methylumbelliferone enhances the effects of chemotherapy on both temozolomide-sensitive and resistant glioblastoma cells.

Published: 8 June 2023 DOI: 10.1038/s41598-023-35045-3
Matías A Pibuel, Daniela Poodts, Sofía A Sias, Agustín Byrne, Silvia E Hajos, Paula G Franco, Silvina L Lompardía

Single-cell transcriptomes reveal heterogeneity of chlorine-induced mice acute lung injury and the inhibitory effect of pentoxifylline on ferroptosis

Published: 26 April 2023 DOI: 10.1038/s41598-023-32093-7
Chen-Qian Zhao, Chong Wang, Meng-Meng Liu, Meng Cao, Jie Peng, De-Qin Kong, Xiao-Ting Ren, Rui Liu, Chun-Xu Hai, Xiao-di Zhang

Protective effect of urotensin II receptor antagonist urantide and exercise training on doxorubicin-induced cardiotoxicity

Published: 23 January 2023 DOI: 10.1038/s41598-023-28437-y
Jing Sun, Jiedong Zhou, Shimin Sun, Hui Lin, Hanlin Zhang, Zuoquan Zhong, Jufang Chi, HangYuan Guo

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

Published: 2 November 2022 DOI: 10.1038/s41598-022-21034-5
Xammy Huu Wrynla, Eddie Wehri, Erik Van Dis, Scott B Biering, Livia H Yamashiro, Chi Zhu, Julien Stroumza, Claire Dugast-Darzacq, Thomas G W Graham, Xuanting Wang, Steffen Jockusch, Chuanjuan Tao, Minchen Chien, Wei Xie, Dinshaw J Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, James J Russo, Jingyue Ju, Anders M Näär, Sarah Stanley, Julia Schaletzky

Homoharringtonine demonstrates a cytotoxic effect against triple-negative breast cancer cell lines and acts synergistically with paclitaxel.

Published: 19 September 2022 DOI: 10.1038/s41598-022-19621-7
Riley Plett, Paul Mellor, Stephanie Kendall, S Austin Hammond, Aren Boulet, Kristine Plaza, Frederick S Vizeacoumar, Franco J Vizeacoumar, Deborah H Anderson

Design, synthesis and biological activities of echinopsine derivatives containing acylhydrazone moiety

Published: 21 February 2022 DOI: 10.1038/s41598-022-06775-7
Peipei Cui, Mingjiang Cai, Yanan Meng, Yan Yang, Hongjian Song, Yuxiu Liu, Qingmin Wang

AEG-1 silencing attenuates M2-polarization of glioma-associated microglia/macrophages and sensitizes glioma cells to temozolomide

Published: 30 August 2021 DOI: 10.1038/s41598-021-96647-3
Jing Li, Yuchen Sun, Xuanzi Sun, Xu Zhao, Yuan Ma, Yuzhu Wang, Xiaozhi Zhang

Potent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin

Published: 28 January 2020 DOI: 10.1038/s41598-020-57843-9
Alexander Herrmann, Manfred Roesner, Thomas Werner, Stefanie M Hauck, Alisha Koch, Amelie Bauer, Martha Schneider, Ruth Brack-Werner

Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms

Published: 9 July 2019 DOI: 10.1038/s41598-019-46163-2
Keli Lima, Jorge Antonio Elias Godoy Carlos, Raquel de Melo Alves-Paiva, Hugo Passos Vicari, Fábio Pires de Souza Santos, Nelson Hamerschlak, Leticia Veras Costa-Lotufo, Fabiola Traina, João Agostinho Machado-Neto