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Scientific Reports

Scientific Reports

IF:3.8 CiteScore:7.5 Articles:19567
We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.

Role of ATP citrate lyase and its complementary partner on fatty acid synthesis in gastric cancer

Published: 3 December 2024 DOI: 10.1038/s41598-024-81448-1
Chunlei Li, Wenxuan Liu, Youzhao Liu, Weixing Wang, Wenhong Deng

Atorvastatin calcium alleviates UVB-induced HaCat cell senescence and skin photoaging

Published: 3 December 2024 DOI: 10.1038/s41598-024-81573-x
Man Li, Yuchen Ge, Shirui Bai, Jing Xia, Guangming Wang, Yaxuan Zhang, Yuanyuan Zhang, Xiaobo Wang, Min Zhou

Inhibitory effect of 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone against NSCLC with L858R/T790M/C797S mutant EGFR

Published: 4 November 2024 DOI: 10.1038/s41598-024-78146-3
Jing Wang, Yuna Wang, Shuanggou Zhang, Yana Qu, Ruohan Zhang, Xuanjun Wang, Jun Sheng, Peiyuan Sun

Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer

Published: 4 November 2024 DOI: 10.1038/s41598-024-76459-x
Nesma Abdelaal, Mohamed A Ragheb, Hamdi M Hassaneen, Emad M Elzayat, Ismail A Abdelhamid

Synergistic effects of bloom helicase (BLM) inhibitor AO/854 with cisplatin in prostate cancer

Published: 23 October 2024 DOI: 10.1038/s41598-024-75938-5
Xiaoyan Ma, Fu Tian, Yuanpin Xiao, Mengqiu Huang, Dandan Song, Xinlin Chen, Houqiang Xu

Genistein inhibits HIF-1α and attenuates high glucose-induced peritoneal mesothelial-mesenchymal transition and fibrosis via the mTOR/OGT pathway

Published: 17 October 2024 DOI: 10.1038/s41598-024-74879-3
Jian Wang, Xin Lv, Yao Lin, Ashanjiang Aniwan, Hongyan Liu, Saijun Zhou, Pei Yu

The activation of the Notch signaling pathway by UBE2C promotes the proliferation and metastasis of hepatocellular carcinoma

Published: 1 October 2024 DOI: 10.1038/s41598-024-72714-3
Ping Zhan, Yuyan Lu, Jing Lu, Yizhe Cheng, Changhong Luo, Fan Yang, Wenqing Xi, Jinzhu Wang, Xuesong Cen, Fuqiang Wang, Chengrong Xie, Zhenyu Yin

Morphine promotes non-small cell lung cancer progression by downregulating E-cadherin via the PI3K/AKT/mTOR pathway

Published: 10 September 2024 DOI: 10.1038/s41598-024-72198-1
Fulei Gu, Yuxuan Zhou, Lili Tian, Jinyan Chen, Can Zhang, Zhangxiang Huang, Weifeng Yu, Kangjie Xie

Protective effects of patchouli alcohol against DSS-induced ulcerative colitis

Published: 20 July 2024 DOI: 10.1038/s41598-024-66259-8
Huifang Han, Min Gao, Fanghong Wang, Zheng Luo, Xuejun Jiang, Yu Qiu, Junhao Su, Xinhao Duan, Shiyue Luo, Shixin Tang, Ahmad Khan, Zhen Zou, Chengzhi Chen, Qi Yin, Jingfu Qiu, Hongyang Zhang

Empagliflozin rescues pro-arrhythmic and Ca2+ homeostatic effects of transverse aortic constriction in intact murine hearts

Published: 8 July 2024 DOI: 10.1038/s41598-024-66098-7
Qiang Wen, Rui Zhang, Kejun Ye, Jun Yang, Hangchuan Shi, Zhu Liu, Yangpeng Li, Ting Liu, Shiyu Zhang, Wanpei Chen, Jingjing Wu, Weichao Liu, Xiaoqiu Tan, Ming Lei, Christopher L-H Huang, Xianhong Ou

Combined effect of gallic acid and zinc ferrite nanoparticles on wheat growth and yield under salinity stress.

Published: 4 June 2024 DOI: 10.1038/s41598-024-63175-9
Qingqin Shao, Lantian Ren, Musarrat Ramzan, Muhammad Baqir Hussain, Rahul Datta, Hesham S Almoallim, Mohammad Javed Ansari, Abdullah Ehsan

Sinomenine treats rheumatoid arthritis by inhibiting MMP9 and inflammatory cytokines expression: bioinformatics analysis and experimental validation

Published: 4 June 2024 DOI: 10.1038/s41598-024-61769-x
Jinfang Luo, Yi Zhu, Yang Yu, Yujie Chen, Kang He, Jianxin Liu

Aggregation of human osteoblasts unlocks self-reliant differentiation and constitutes a microenvironment for 3D-co-cultivation with other bone marrow cells

Published: 6 May 2024 DOI: 10.1038/s41598-024-60986-8
Sabrina Marozin, Birgit Simon-Nobbe, Astrid Huth, Evelyn Beyerer, Laurenz Weber, Andreas Nüssler, Günter Lepperdinger

Tenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells

Published: 1 April 2024 DOI: 10.1038/s41598-024-58499-5
Sha Lv, Qianrong Pan, Weijin Lu, Weisong Zhang, Naike Wang, Lijuan Huang, Lianjing Li, Jieyao Liu, Jiamei Ma, Zhan Li, Yong Huang, Qiudi Deng, Xueping Lei

A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation and PDE activity

Published: 23 February 2024 DOI: 10.1038/s41598-024-55038-0
Dareen Mikheil, Matthew A Larsen, Kevin Hsiao, Nathan H Murray, Tim Ugo, Hui Wang, Said A Goueli

Ripa-56 protects retinal ganglion cells in glutamate-induced retinal excitotoxic model of glaucoma

Published: 15 February 2024 DOI: 10.1038/s41598-024-54075-z
Lemeng Feng, Shirui Dai, Cheng Zhang, Wulong Zhang, Weiming Zhu, Chao Wang, Ye He, Weitao Song

Identification of potential inhibitor against Leishmania donovani mitochondrial DNA primase through in-silico and in vitro drug repurposing approaches

Published: 8 February 2024 DOI: 10.1038/s41598-024-53316-5
Mitul Nath, Deep Bhowmik, Satabdi Saha, Rajat Nandi, Diwakar Kumar

Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella

Published: 8 February 2024 DOI: 10.1038/s41598-024-53542-x
Liliana S Mendonça, Daniel Henriques, Vanessa Fernandes, Ricardo Moreira, João Brás, Sónia Duarte, Jens C Schwamborn, Luís Pereira de Almeida

Exploring the mechanism and phytochemicals in Psoraleae Fructus-induced hepatotoxicity based on RNA-seq, in vitro screening and molecular docking

Published: 19 January 2024 DOI: 10.1038/s41598-023-50454-0
Huiying Shang, Xian Liu, Jinchao Pan, Hongbo Cheng, Zengchun Ma, Chengrong Xiao, Yue Gao