2-Methoxyethyl acetate
Product identifier
- Product name: 2-Methoxyethyl acetate
- CBnumber: CB8852810
- CAS: 110-49-6
- EINECS Number: 203-772-9
- Synonyms: 2-Methoxyethyl acetate,methoxyethyL acetate
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Acute toxicity - Category 4, Inhalation
Reproductive toxicity, Category 1B
Label elements
Pictogram(s)
- Signal wordDanger
H226 Flammable liquid and vapour
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P203 Obtain, read and follow all safety instructions before use.
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: 2-Methoxyethyl acetate
- Synonyms: 2-Methoxyethyl acetate,methoxyethyL acetate
- CAS: 110-49-6
- EC number: 203-772-9
- MF: C5H10O3
- MW: 118.13
Description of first aid measures
If inhaledFresh air, rest. Refer for medical attention.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention .
Most important symptoms and effects, both acute and delayed
May cause irritation if splashed into eyes. Can be absorbed through the skin. Swallowing a large single dose or absorbing larged amount through skin could result in death. It is unlikely that air levels of the compound would be dangerous unless it is heated. (USCG, 1999)
Indication of any immediate medical attention and special treatment needed
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Ethylene glycol, glycols, and related compounds
Extinguishing media
To fight fire, use CO2, dry chemical.
Specific Hazards Arising from the Chemical
Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon monoxide, may be formed when involved in fire. (USCG, 1999)
Advice for firefighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
NFPA 704
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
1. remove all ignition sources. 2. ventilate area of spill or leak. 3. for small quantities, absorb on paper towels. evaporate in safe place (such as fume hood). allow sufficient time...to completely clear hood ductwork. burn paper in suitable location away from combustible materials. large quantities can be collected & atomized in suitable combustion chamber. liq...should not be allowed to enter confined space, such as sewer, because of possibility of explosion.
Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 45°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong oxidants, strong bases and strong acids. Keep in the dark.Fire proof. Separated from strong oxidants, strong bases, strong acids. Keep in the dark.
Control parameters
Occupational Exposure limit valuesTLV: 0.1 ppm as TWA; (skin); BEI issued.MAK: 4.9 mg/m3, 1 ppm; peak limitation category: II(8); skin absorption (H); pregnancy risk group: B.EU-OEL: 1 ppm as TWA; (skin)
no data available
Exposure controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear safety goggles or eye protection in combination with breathing protection.
Protective gloves. Protective clothing.
Use ventilation, local exhaust or breathing protection.
no data available
Information on basic physicochemical properties
- Physical stateSolid
- ColourWhite
- Odour
Pleasant odor
- Melting point/freezing point
294°C(lit.)
- Boiling point or initial boiling point and boiling range
145°C(lit.)
- Flammability
Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.
- Lower and upper explosion limit/flammability limit1.7-8.8%(V)
- Flash point
46°C
- Auto-ignition temperature
740° F (USCG, 1999)
- Decomposition temperature
no data available
- pH
no data available
- Kinematic viscosity
1.1 cP at 25 deg C
- SolubilitySoluble in alcohol and ether (Weast, 1986).
- Partition coefficient n-octanol/water
log Kow = 0.10 (est)
- Vapour pressure4.7 hPa (20 °C)
- Density and/or relative density
1.009g/mLat 25°C(lit.)
- Relative vapour density
4.07 (NTP, 1992) (Relative to Air)
- Particle characteristics
no data available
Reactivity
The substance can presumably form explosive peroxides. Reacts with strong oxidants and strong bases.
Chemical stability
no data available
Possibility of hazardous reactions
MODERATE /FIRE HAZARD/ WHEN EXPOSED TO HEAT OR FLAME; CAN REACT WITH OXIDIZING MATERIALSEsters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Conditions to avoid
no data available
Incompatible materials
Nitrates, strong oxidizers, alkalis & acids
Hazardous decomposition products
When heated to decomposition it emits acrid smoke and fumes.
Acute toxicity
- Oral: LD50 Rat oral 3.93 g/kg
- Inhalation: LC50 Cat inhalation 2500 ppm for 9 hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The vapour is mildly irritating to the eyes. The substance may cause effects on the bone marrow and central nervous system. The substance may cause effects on the blood at high levels. This may result in lesions of blood cells and kidney impairment. Exposure far above the OEL could cause unconsciousness.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the bone marrow and blood. This may result in lesions of blood cells and kidney impairment. May cause toxicity to human reproduction or development.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill); Conditions: static bioassay in fresh water at 23 deg C, mild aeration applied after 24 hr; Concentration: 45 ppm for 96 hr
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Methyl cellosolve present at 100 mg/L, reached 86.9% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Methyl cellosolve acetate reached 30% of its theoretical BOD after 5 days using a sewage seed(2). 69% of the theoretical BOD for methyl cellosolve acetate was reached over a period of 10 days in a biodegradation study employing dispersed seed aeration(3).
Bioaccumulative potential
An estimated BCF of 3.2 was calculated for methyl cellosolve acetate(SRC), using an estimated log Kow of 0.10(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of methyl cellosolve acetate is estimated as approximately 30(SRC), using an estimated log Kow of 0.10(1) and a regression-derived equation(2). According to a recommended classification scheme(3), this estimated Koc value suggests that methyl cellosolve acetate is expected to have very high mobility in soil(SRC).
Other adverse effects
no data available
Disposal methods
ProductThe material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: UN1189 (For reference only, please check.)
IMDG: UN1189 (For reference only, please check.)
IATA: UN1189 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ETHYLENE GLYCOL MONOMETHYL ETHER ACETATE (For reference only, please check.)
IMDG: ETHYLENE GLYCOL MONOMETHYL ETHER ACETATE (For reference only, please check.)
IATA: ETHYLENE GLYCOL MONOMETHYL ETHER ACETATE (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 3 (For reference only, please check.)
IMDG: 3 (For reference only, please check.)
IATA: 3 (For reference only, please check.)
Packing group, if applicable
ADR/RID: III (For reference only, please check.)
IMDG: III (For reference only, please check.)
IATA: III (For reference only, please check.)
Environmental hazards
ADR/RID: No
IMDG: No
IATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Check for peroxides prior to distillation; eliminate if found.Health effects of exposure to the substance have not been investigated adequately.Its effects are deduced from those of similar substances.
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.