Chemical Safety Data Sheet MSDS / SDS

Acetic acid

Revision Date:2024-03-02Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: Acetic acid
  • CBnumber: CB7854064
  • CAS: 64-19-7
  • EINECS Number: 200-580-7
  • Synonyms: acetic acid,AcOH

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

  • Symbol(GHS)
  • Signal wordDanger
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
Hazard statements
H226 Flammable liquid and vapour
H314 Causes severe skin burns and eye damage

SECTION 3: Composition/information on ingredients

Substance

  • Product name: Acetic acid
  • Synonyms: acetic acid,AcOH
  • CAS: 64-19-7
  • EC number: 200-580-7
  • MF: C2H4O2
  • MW: 60.05

SECTION 4: First aid measures

Description of first aid measures

General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media
Dry powder Dry sand
Unsuitable extinguishing media
Do NOT use water jet.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

Use water spray to cool unopened containers.

NFPA 704

3
2
0
HEALTH 3 Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid)
FIRE 2 Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas.

Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.

For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations (see section 13).

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Avoid inhalation of vapour or mist.

Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Moisture sensitive.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment
Eye/face protection

Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: butyl-rubber

Minimum layer thickness: 0,3 mm Break through time: 480 min

Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)

Splash contact

Material: Nature latex/chloroprene Minimum layer thickness: 0,6 mm Break through time: 32 min

Material tested:Lapren? (KCL 706 / Aldrich Z677558, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Exposure limits
TLV-TWA 10 ppm ~25 mg/m3) (ACGIH, OSHA, and MSHA); TLV-STEL 15 ppm (37.5 mg/m3) (ACGIH).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Appearancecolourless liquid
  • Odourstinging
  • Odour Threshold0.006ppm
  • pH2,5 at 50 g/l at 20 °C
  • Melting point/freezing pointMelting point/range: 16,2 °C - lit.
  • Initial boiling point and boiling range117 - 118 °C - lit.
  • Flash point39 °C - closed cup
  • Evaporation rateNo data available
  • Flammability (solid, gas)Not applicable
  • Upper/lower flammability or explosive limitsUpper explosion limit: 19,9 %(V)Lower explosion limit: 4 %(V)
  • Vapour pressure20,79 hPa at 25 °C
  • Vapour density2,07
  • Relative density1,049 g/cm3 at 25 °C
  • Water solubility602,9 g/l at 25 °C at 1.013 hPa - completely soluble
  • Partition coefficient: n-octanol/waterlog Pow: -0,17 at 25 °C - Bioaccumulation is not expected., (ECHA)
  • Autoignition temperature 463 °C
  • Decomposition temperature Distillable in an undecomposed state at normal pressure.
  • Viscosity1,17 mm2/s at 20 °C -
  • Explosive propertiesNo data available
  • Oxidizing propertiesNo data available
  • Henry's Law Constant133, 122, 6.88, and 1.27 at pH values of 2.13, 3.52, 5.68, and 7.14, respectively (25 °C, Hakuta et al., 1977)
  • λmaxλ: 260 nm Amax: 0.05
    λ: 270 nm Amax: 0.02
    λ: 300 nm Amax: 0.01
    λ: 500 nm Amax: 0.01

Other safety information

Surface tension 28,8 mN/m at 10,0 °C


Relative vapour density

2,07

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

Heat, flames and sparks.

Incompatible materials

Oxidizing agents, Soluble carbonates and phosphates, Hydroxides, Metals, Peroxides, permanganates, for example potassium permanganate, Amines, Alcohols, Nitric acid

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity
LD50 Oral - Rat - 3.310 mg/kg
Remarks: (RTECS)
LC50 Inhalation - Mouse - 4 h - 2.819 mg/l Remarks: (RTECS)
Skin corrosion/irritation
Skin - Rabbit
Result: Causes burns. - 4 h (OECD Test Guideline 404) Remarks: (IUCLID)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes burns. - 4 h (OECD Test Guideline 405) Remarks: (IUCLID)
Causes serious eye damage.
Respiratory or skin sensitisation
No data available
Germ cell mutagenicity
Ames test
Salmonella typhimurium Result: negative
Mutagenicity (mammal cell test): chromosome aberration. Chinese hamster ovary cells
Result: negative
Mutagenicity (micronucleus test)
Rat - male and female - Bone marrow Result: negative
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: AF1225000
Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation
and edema of the bronchi, pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Ingestion or inhalation of concentrated acetic acid causes damage to tissues of the respiratory and digestive tracts. Symptoms include: hematemesis, bloody diarrhea, edema and/or perforation of the esophagus and pylorus, pancreatitis, hematuria, anuria, uremia, albuminuria, hemolysis, convulsions, bronchitis, pulmonary edema, pneumonia, cardiovascular collapse, shock, and death. Direct contact or exposure to high concentrations of vapor with skin or eyes can cause: erythema, blisters, tissue destruction with slow healing, skin blackening, hyperkeratosis, fissures, corneal erosion, opacification, iritis, conjunctivitis, and possible blindness.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Toxicity
LD50 in rats (g/kg): 3.53 orally (Smyth)

SECTION 12: Ecological information

Toxicity

Toxicity to fish
semi-static test LC50 - Oncorhynchus mykiss (rainbow trout) - >

1.000 mg/l - 96 h

(OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - > 1.000 mg/l - 48 h (OECD Test Guideline 202)

Toxicity to algae
static test EC50 - Skeletonema costatum - > 1.000 mg/l - 72 h (ISO 10253)

Toxicity to bacteria
EC5 - Pseudomonas putida - 2.850 mg/l - 16 h

Remarks: neutral(maximum permissible toxic concentration)(Lit.)

microtox test EC50 - Photobacterium phosphoreum - 11 mg/l - 15 min

Remarks: (IUCLID)

Persistence and degradability

Biodegradability Result: 99 % - Readily biodegradable.

(OECD Test Guideline 301D) Remarks: (HSDB)

Result: 95 % - Readily eliminated from water (OECD Test Guideline 302B)

Biochemical Oxygen Demand (BOD)

880 mg/g Remarks: (Lit.)

Ratio BOD/ThBOD 76 %

Remarks: (IUCLID)

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Additional ecological information

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

Incompatibilities

Acetic acid reacts with alkaline substances.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: 2789 IMDG: 2789 IATA: 2789

UN proper shipping name


ADR/RID: ACETIC ACID, GLACIAL IMDG: ACETIC ACID, GLACIAL


IATA: Acetic acid, glacial

14.3

Transport hazard class(es)

ADR/RID: 8 (3) IMDG: 8 (3)


IATA: 8 (3)

14.4

Packaging group

ADR/RID: II IMDG: II


IATA: II

14.5

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no


IATA: no

14.6

Special precautions for user

No data available


SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals
China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/
Measures for Environmental Management of New Chemical Substances
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/
EC Inventory:Listed.
European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/
Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr
New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/
Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/
United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/
Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • CAS: Chemical Abstracts Service
  • EC50: Effective Concentration 50%
  • IATA: International Air Transportation Association
  • IMDG: International Maritime Dangerous Goods
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • STEL: Short term exposure limit
  • TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

UN number 2789 is for acetic acid, glacial or acetic acid solution, more than 80% acid by mass.Other UN numbers: UN 2790 acetic acid solution (10-80% acetic acid); UN hazard class 8, packing group II-III.
Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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