Chemical Safety Data Sheet MSDS / SDS

Chloral hydrate

Revision Date:2024-04-20Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Chloral hydrate
CBnumber: CB0198709
CAS: 302-17-0
EINECS Number: 206-117-5
Synonyms: TCA,chloral hydrate

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Hazard statements

H301 Toxic if swalloed

H302 Harmful if swallowed

H312 Harmful in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H332 Harmful if inhaled

Disposal

WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/chloral-hydrate

SECTION 3: Composition/information on ingredients

Substance

Product name: Chloral hydrate
Synonyms: TCA,chloral hydrate
CAS: 302-17-0
EC number: 206-117-5
MF: C2H3Cl3O2
MW: 165.4

SECTION 4: First aid measures

Description of first aid measures

General advice

First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Use extinguishing measures that are appropriate to local circumstances and the

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Hydrogen chloride gas Not combustible.

Ambient fire may liberate hazardous vapours.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

NFPA 704

HEALTH	2	Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE	1	Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
REACT	1	Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.

Air and light sensitive.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril? L

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:KCL 741 Dermatril? L

Body Protection

protective clothing

Respiratory protection

required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Recommended Filter type: Filter type P3

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancewhite crystalline
OdourNo data available
Odour ThresholdNo data available d) pH 3,5 - 4,4 at 100 g/l Melting point/freezing point Initial boiling point and boiling range Melting point/range: 57 °C - lit. 100,66 °C at 973,8 hPa - OECD Test Guideline 103 Flash point Not applicable Evaporation rate No data available Flammability (solid, gas) Upper/lower flammability or explosive limits No data available No data available Vapour pressure 20 hPa at 25 °C Vapour density No data available Relative density No data available Water solubility 443,69 g/l at 25 °C - completely soluble Partition coefficient: n-octanol/water Autoignition temperature Decomposition temperature log Pow: 1,092 at 25 °C - Bioaccumulation is not expected. No data available No data available Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available Explosive properties No data available Oxidizing properties No data available
Melting point/freezing pointMelting point/range: 57 °C - lit.
Initial boiling point and boiling range100,66 °C at 973,8 hPa - OECD Test Guideline 103
Flash pointNot applicable
Evaporation rate16 °C
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsNo data available
Vapour pressure 20 hPa at 25 °C
Vapour density No data available
Relative densityNo data available
Water solubility443,69 g/l at 25 °C - completely soluble
Partition coefficient: n-octanol/waterlog Pow: 1,092 at 25 °C - Bioaccumulation is not expected.
Autoignition temperatureNo data available
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available

Other safety information

No data available

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Violent reactions possible with: Strong oxidizing agents permanganates

Alcohols Bases

Alkali metals

Alkaline earth metals tannin

Conditions to avoid

Air Light.

no information available

Incompatible materials

iron/iron-containing compounds, various plasticsStrong oxidizing agents

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

Acute toxicity estimate Oral - 100,1 mg/kg (Expert judgment)
Acute toxicity estimate Oral - 100,1 mg/kg (Expert judgment)
LC50 Inhalation - Rat - 4 h - 0,44 mg/l Remarks: (in analogy to similar products)
The value is given in analogy to the following substances: 2,2,2-trichloroacetaldehyde; chloral
LD50 Dermal - Rat - 3.030 mg/kg Remarks: (ECHA)

Skin corrosion/irritation

Skin - Guinea pig Result: Skin irritation Remarks: (ECHA)

Serious eye damage/eye irritation

No data available

Respiratory or skin sensitization

Remarks: (ECHA)

Germ cell mutagenicity

Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation Result: negative
Remarks: (ECHA)
Test Type: in vivo assay Species: Mouse
Application Route: Intraperitoneal Method: OECD Test Guideline 474 Result: negative

Carcinogenicity

No data available

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

Inhalation - May cause damage to organs through prolonged or repeated exposure. - Lungs, Adrenal gland
The value is given in analogy to the following substances: 2,2,2-trichloroacetaldehyde; chloral

Aspiration hazard

No data available

Toxicity

LD50 oral in rat: 479mg/kg

SECTION 12: Ecological information

Toxicity

Toxicity to fish

static test LC50 - Danio rerio (zebra fish) - > 100 mg/l - 96 h (OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia magna (Water flea) - 500 mg/l - 48 h

Toxicity to algae

IC50 - Scenedesmus quadricauda (Green algae) - 2,8 mg/l - 168 h

Toxicity to bacteria

- Bacteria - 1,6 mg/l - 16 h

- Protozoa - 79 mg/l - 72 h

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 44,04 % - Not inherently biodegradable. (OECD Test Guideline 301F)

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Incompatibilities

Chloral hydrate reacts with strong bases forming chloroform. Contact with acids, or exposure to light may cause polymerization. Reacts with water, forming chloral hydrate. Reacts with oxidizers, with a risk of fire or explosions.

Waste Disposal

Incineration after mixing with another combustible fuel; care must be taken to assure complete combustion to prevent phosgene formation; an acid scrubber is necessary to remove the halo acids produced.

SECTION 14: Transport information

UN number

ADR/RID: 2811 IMDG: 2811 IATA: 2811

UN proper shipping name

ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. (chloral, monohydrate) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (chloral, monohydrate) IATA: Toxic solid, organic, n.o.s. (chloral, monohydrate)

Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

Packaging group

ADR/RID: I IMDG: I IATA: I

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Not Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

EC Inventory:Listed.

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
CAS: Chemical Abstracts Service
EC50: Effective Concentration 50%
IATA: International Air Transportation Association
IMDG: International Maritime Dangerous Goods
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
STEL: Short term exposure limit
TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Use of alcoholic beverages enhances the harmful effect.Depending on the degree of exposure, periodic medical examination is suggested.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.