Chemical Safety Data Sheet MSDS / SDS
Chloroacetic acid
Revision Date:2026-04-11Revision Number:1
Product identifier
- Product name: Chloroacetic acid
- CBnumber: CB2854397
- CAS: 79-11-8
- EINECS Number: 201-178-4
- Synonyms: chloroacetic acid,mca
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P273 Avoid release to the environment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Hazard statements
H400 Very toxic to aquatic life
H335 May cause respiratory irritation
H314 Causes severe skin burns and eye damage
Substance
- Product name: Chloroacetic acid
- Synonyms: chloroacetic acid,mca
- CAS: 79-11-8
- EC number: 201-178-4
- MF: C2H3ClO2
- MW: 94.5
General advice
First aiders need to protect themselves. Show this safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.
If swallowed
If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. Do not attempt to neutralise.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Combustible. Vapours are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products
Carbon oxides Hydrogen chloride gas
Specific extinguishing methods
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
NFPA 704
4
1
0
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture.
Storage
Further information on storage conditionsTightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorised persons.
Storage class
6.1A, Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
Recommended storage temperature
Recommended storage temperature see product label.
Packaging material
Suitable material: Poly Drum
Ingredients with workplace control parameters
halable fraction and vapor)
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter A-(P3)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Tightly fitting safety goggles
Skin and body protection
Tightly fitting safety goggles
Acid-resistant protective clothing
Hand protection
Material
Latex gloves
Break through time
480 min
Glove thickness
0.6 mm
Protective index
Full contact
Manufacturer
Lapren® (KCL 706 / Aldrich Z677558, Size M)
Material
Nitrile rubber
Break through time
30 min
Glove thickness
0.4 mm
Protective index
Splash contact
Manufacturer
Camatril® (KCL 730 / Aldrich Z677442, Size M)
Remarks
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D- 36124 Eichenzell, Internet: www.kcl.de).
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Information on basic physicochemical properties
- Dielectric constant12.3（60℃）
- Physical stateLiquid
- SolubilitySoluble in methanol, acetone, diethyl ether, benzene, chloroform and ethanol.
- Particle characteristics Particle sizeNo data available
- Molecular weight94.50 g/mol
- Surface tension73.1 mN/m, 20 °C, OECD Test Guideline 115, GLP: yes
- Oxidizing propertiesnone
- Explosive propertiesNot classified as explosive.
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamic1.29 mPa.s ( 100 °C)
- Autoignition temperature470 °C
Decomposition temperature Viscosity: No data available - Partition coefficient: n-octanol/waterlog Pow: 0.49
Method: OECD Test Guideline 107
GLP: yes Bioaccumulation is not expected. - Water solubility1,000 g/l miscible (20 °C)
- Density1.64 g/cm3 (20 °C)
Method: OECD Test Guideline 109
GLP: yes - Relative density1.64 (20 °C)
Method: OECD Test Guideline 109
GLP: yes - Relative vapor density3.26 (vs air)
- Vapor pressure0.0213 hPa (20 °C)
Method: OECD Test Guideline 104
GLP: yes - Lower explosion limit / Lower flammability limitLower explosion limit
- Upper explosion limit / Upper flammability limit8%
- Self-ignition475 °C > 1,011.9 - < 1,022 hPa
Method: DIN 51794
GLP: yes - Burning rateNo data available
- Evaporation rateNo data available
- Flash point126 °C
Method: closed cup - Boiling point/boiling range189 °C
Method: lit. - Melting point/ range60 - 63 °C
Method: lit. - pH0.86
Method: OECD Test Guideline 105
GLP: yes - pH< 1.0 (20 °C)
Concentration (External MSDS): 800 g/l - Odor ThresholdNo data available
- OdorPenetrating, burning odor
- Colorwhite
- Appearancecrystalline
Reactivity
Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical. The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Generates dangerous gases or fumes in contact with: sodium carbonate calcium carbonate Potassium carbonate Sulphides Metals Exothermic reaction with: Amines bases Reducing agents Strong oxidizing agents Sulphides hydrogen peroxide Risk of explosion with: furfuryl alcohol hydrogen peroxide
Conditions to avoid
Strong heating.
Incompatible materials
No data available
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - female - 90.4 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - > 1.268 mg/l - dust/mist (OECD Test Guideline 403)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
LD50 Dermal - Rat - female - 305 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
LC50 Inhalation - Rat - male and female - 4 h - > 1.268 mg/l - dust/mist (OECD Test Guideline 403)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
LD50 Dermal - Rat - female - 305 mg/kg (OECD Test Guideline 402)
Skin - Rabbit
Result: Corrosive - 24 h
Remarks: (ECHA)
Serious eye damage/eye irritation
Result: Corrosive - 24 h
Remarks: (ECHA)
Eyes - Rabbit
Result: Irreversible effects on the eye
Remarks: Causes serious eye damage.
(ECHA)
Respiratory or skin sensitization
Result: Irreversible effects on the eye
Remarks: Causes serious eye damage.
(ECHA)
Local lymph node assay (LLNA) - Mouse
Result: Not a skin sensitizer.
(OECD Test Guideline 429)
Germ cell mutagenicity
Result: Not a skin sensitizer.
(OECD Test Guideline 429)
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
Test Type: DNA binding study
Species: Mouse
Application Route: Oral
Result: negative
Remarks: (ECHA)
Carcinogenicity
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Result: negative
Remarks: (ECHA)
Test Type: DNA binding study
Species: Mouse
Application Route: Oral
Result: negative
Remarks: (ECHA)
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation. - Respiratory Tract
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 90 d - Lowest observed ad- verse effect level - 30 mg/kg
Remarks: Subchronic toxicity
RTECS: AF8575000
Remarks: Subchronic toxicity
RTECS: AF8575000
Ecotoxicity
Components:
chloroacetic acid:
Toxicity to fishLC50 (Poecilia reticulata (guppy)): 369 mg/l Exposure time: 96 h Test Type: static test Remarks: (ECHA)
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 74.2 mg/l End point: Immobilization Exposure time: 48 h Test Type: static test Analytical monitoring: yes Method: OECD Test Guideline 202
Toxicity to algae/aquatic plants
ErC50 (Desmodesmus subspicatus (green algae)): 0.033 mg/l Exposure time: 72 h Test Type: static test Method: OECD Test Guideline 201 GLP: yes NOEC (Desmodesmus subspicatus (green algae)): 0.006 mg/l Exposure time: 72 h Test Type: static test Method: OECD Test Guideline 201 GLP: yes
M-Factor (Acute aquatic toxicity)
10
Toxicity to fish (Chronic toxicity)
NOEC (Danio rerio (zebra fish)): < 25 mg/l End point: mortality Exposure time: 35 d Test Type: semi-static test Analytical monitoring: yes Method: OECD Test Guideline 210 GLP: yes
Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)
NOEC (Daphnia magna (Water flea)): 32 mg/l Exposure time: 21 d Test Type: semi-static test Remarks: (ECHA)
Ecotoxicology Assessment
Chronic aquatic toxicityThis product has no known ecotoxicological effects.
Persistence and degradability
Components:
chloroacetic acid:
Biodegradabilityaerobic Inoculum: activated sludge, non-adapted Result: Readily biodegradable. Biodegradation: 69 % Exposure time: 28 d GLP: yes Remarks: (ECHA)
Bioaccumulative potential
Components:
chloroacetic acid:
Partition coefficient: noctanol/waterlog Pow: 0.49 Method: OECD Test Guideline 107 GLP: yes Remarks: Bioaccumulation is not expected.
Mobility in soil
No data available
Other adverse effects
No data available
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : UN 1751
Proper shipping name : Chloroacetic acid, solid
Class : 6.1
Subsidiary risk : 8
Packing group : II
Labels : Division 6.1 - Toxic substances, Class 8 - Corrosive substances
Packing instruction (cargo aircraft) : 675
Packing instruction (passenger aircraft) : 668
Proper shipping name : Chloroacetic acid, solid
Class : 6.1
Subsidiary risk : 8
Packing group : II
Labels : Division 6.1 - Toxic substances, Class 8 - Corrosive substances
Packing instruction (cargo aircraft) : 675
Packing instruction (passenger aircraft) : 668
IMDG-Code
UN number : UN 1751
Proper shipping name : CHLOROACETIC ACID, SOLID
Class : 6.1
Subsidiary risk : 8
Packing group : II
Labels : 6.1 (8)
EmS Code : F-A, S-B
Marine pollutant : yes
Proper shipping name : CHLOROACETIC ACID, SOLID
Class : 6.1
Subsidiary risk : 8
Packing group : II
Labels : 6.1 (8)
EmS Code : F-A, S-B
Marine pollutant : yes
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National Regulations
JT/T 617
UN number : UN 1751
Proper shipping name : CHLOROACETIC ACID, SOLID
Class : 6.1
Subsidiary risk : 8
Packing group : II
Labels : 6.1 (8)
Environmentally hazardous : no
Proper shipping name : CHLOROACETIC ACID, SOLID
Class : 6.1
Subsidiary risk : 8
Packing group : II
Labels : 6.1 (8)
Environmentally hazardous : no
Special precautions for user
The transport classification(s) provided herein are for informational purposes only, and solely based upon the properties of the unpackaged material as it is described within this Safety Data Sheet. Transportation classifications may vary by mode of transportation, package sizes, and variations in regional or country regulations.
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals
Listed
Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)
No. / Code Chemical name / Category Threshold quantity
J5 Acute toxic 500 t
Hazardous Chemicals for Priority Management
Not listed under SAWS
Catalogue of Specially Controlled Hazardous
Not listed Chemicals
List of Explosive Precursors
Not listed
Regulations on Labour Protection in Workplaces where Toxic Substances are Used
Catalogue of Highly Toxic Chemicals
Not listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not listed
Regulation on the Administration of Precursor Chemicals
Catalogue and Classification of Precursor Chemicals
Not listed
Regulations on the Administration of Controlled Chemicals
List of Controlled Chemicals
Not listed
Regulations of Ozone Depleting Substances Management
List of Controlled Ozone Depleting Substances
Not listed
List of Controlled Ozone Depleting Substances Import and Export
Not listed
Environmental Protection Law
List of Priority Controlled Chemicals
Not listed
List of Key Controlled New Pollutants
Not listed
Full text of other abbreviations
ACGIHUSA. ACGIH Threshold Limit Values (TLV)
GBZ 2.1-2007
Occupational exposure limits for hazardous agents in the workplace - Chemical hazardous agents.
ACGIH / TWA
8-hour, time-weighted average
GBZ 2.1-2007 / MAC AIIC - Australian Invent Transport by Land of Bra bw - Body weight; CMR Standard of the German List (Canada); ECx - Conc associated with x% respo Chemical Substances (Jap response; ERG - Emerge GLP - Good Laboratory P cer; IATA - International Construction and Equipm Half maximal inhibitory c tion; IECSC - Inventory o tional Maritime Dangerou Industrial Safety and H Standardisation; KECI - K tration to 50 % of a test (Median Lethal Dose); MA lution from Ships; MERC of Dangerous Goods; n.o. - No Observed (Adverse) fect Level; NOELR - No Norm; NTP - National Toxi icals; OECD - Organisatio fice of Chemical Safety a and Toxic substance; PIC stances; (Q)SAR - (Quant (EC) No 1907/2006 of th Registration, Evaluation, Accelerating Decompositi Chemical Substance Inve Thailand Existing Chemica States); UN - United Nat Transport of Dangerous WHMIS - Workplace Hazar
Maximum allowable concentration ry of Industrial Chemicals
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonised System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organisation
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- SUR - The Agreement for the Facilitation of the Transport . - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC ffect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
ANTT - National Agency for il
ASTM - American Society for the Testing of Materials
- Carcinogen, Mutagen or Reproductive Toxicant
DIN nstitute for Standardisation
DSL - Domestic Substances ntration associated with x% response
ELx - Loading rate se
EmS - Emergency Schedule
ENCS - Existing and New n)
ErCx - Concentration associated with x% growth rate cy Response Guide
GHS - Globally Harmonised System
actice
IARC - International Agency for Research on Canir Transport Association
IBC - International Code for the nt of Ships carrying Dangerous Chemicals in Bulk
IC50 ncentration
ICAO - International Civil Aviation Organiza- Existing Chemical Substances in China
IMDG - Interna- Goods
IMO - International Maritime Organisation
ISHL alth Law (Japan)
ISO - International Organisation for rea Existing Chemicals Inventory
LC50 - Lethal Concenopulation
LD50 - Lethal Dose to 50% of a test population POL - International Convention for the Prevention of Pol- SUR - The Agreement for the Facilitation of the Transport . - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC ffect Concentration
NO(A)EL - No Observed (Adverse) Efbservable Effect Loading Rate
NOM - Official Mexican ology Program
NZIoC - New Zealand Inventory of Chemfor Economic Co-operation and Development
OPPTS - Ofd Pollution Prevention
PBT - Persistent, Bioaccumulative S - Philippines Inventory of Chemicals and Chemical Subtative) Structure Activity Relationship
REACH - Regulation European Parliament and of the Council concerning the uthorisation and Restriction of Chemicals
SADT - Selfn Temperature
SDS - Safety Data Sheet
TCSI - Taiwan tory
TDG - Transportation of Dangerous Goods
TECI s Inventory
TSCA - Toxic Substances Control Act (United ons
UNRTDG - United Nations Recommendations on the oods
vPvB - Very Persistent and Very Bioaccumulative
ous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.