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ChemicalBook > Product Catalogue >Natural Products >Alkaloids >ALPHA-AMANITIN

ALPHA-AMANITIN

ALPHA-AMANITIN Structure
  • ₹32290.98
  • Product name: ALPHA-AMANITIN
  • CAS: 23109-05-9
  • MF: C39H54N10O14S
  • MW: 918.98
  • EINECS:245-432-2
  • MDL Number:MFCD30207890
  • Synonyms:Aids004473;Aids-004473;AMANITIN, a-(RG);AMANITIN, a-(RG)(CALL);cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide;alpha-AMantine, froM AManita Phalloides;AMANITIN, A-;ALPHA-AMANITIN
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberA2263
  • Product descriptionα-Amanitin from Amanita phalloides, ≥85% (HPLC), powder
  • Packaging1MG
  • Price₹32290.98
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A2263 α-Amanitin from Amanita phalloides, ≥85% (HPLC), powder 1MG ₹32290.98 2022-06-14 Buy

Properties

Melting point :254-255 °C(lit.)
alpha :D20 +191°
Boiling point :1622.2±65.0 °C(Predicted)
Density :1.1626 (rough estimate)
refractive index :1.7400 (estimate)
storage temp. :−20°C
solubility :H2O: 1.0 mg/mL
form :powder
pka :9.63±0.70(Predicted)
color :white to light yellow
biological source :Amanita phalloides
optical activity :+19120 (H2O)
Water Solubility :Soluble to 5 mM in ethanol and to 5 mM in water
ε(extinction coefficient) :13,500 at 310nm in H2O at 1M
Merck :13,370
BRN :1071138
InChIKey :CIORWBWIBBPXCG-PWKRRBCNNA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.
P405 Store locked up.

Description

α-Amanitin is a cyclic peptide found in several species of the Amanita genus as well as other poisonous fungi. At 1, 10, and 50 μg/ml, respectively, α-amanitin inhibits RNA polymerase II, III, and IV, preventing translocation of the enzymes on DNA, which significantly slows the rate of transcription. RNA polymerase I is insensitive to its effects. This toxin is used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.

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