(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
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- $37 - $650
- Product name: (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
- CAS: 5652-28-8
- MF: C3H8NO5P
- MW: 169.07
- EINECS:
- MDL Number:MFCD00014350
- Synonyms:(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST;2-Amino-3-phosphonopropionic acid;2-AP3;Alanine, 3-phosphono-
6 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Medical Isotopes, Inc.
- TRC
Package
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number0120BA
- Product descriptionDL-2-Amino-3-phosphonopropionic acid
- Packaging50mg
- Price$139
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13852
- Product descriptionDL-AP3 ≥95%
- Packaging50mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13852
- Product descriptionDL-AP3 ≥95%
- Packaging100mg
- Price$68
- Updated2024-03-01
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number38685
- Product descriptionDL-2-Amino-3-phosphonopropionic acid
- Packaging250mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA627553
- Product descriptionDL-2-Amino-3-phosphonopropionicAcid(AP3)
- Packaging100mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA627553
- Product descriptionDL-2-Amino-3-phosphonopropionicAcid(AP3)
- Packaging250mg
- Price$160
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 0120BA | DL-2-Amino-3-phosphonopropionic acid | 50mg | $139 | 2021-12-16 | Buy |
| Cayman Chemical | 13852 | DL-AP3 ≥95% | 50mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 13852 | DL-AP3 ≥95% | 100mg | $68 | 2024-03-01 | Buy |
| Medical Isotopes, Inc. | 38685 | DL-2-Amino-3-phosphonopropionic acid | 250mg | $650 | 2021-12-16 | Buy |
| TRC | A627553 | DL-2-Amino-3-phosphonopropionicAcid(AP3) | 100mg | $75 | 2021-12-16 | Buy |
| TRC | A627553 | DL-2-Amino-3-phosphonopropionicAcid(AP3) | 250mg | $160 | 2021-12-16 | Buy |
Properties
Boiling point :481.6±55.0 °C(Predicted)
Density :1.763±0.06 g/cm3(Predicted)
solubility :PBS (pH 7.2): 2 mg/ml
form :White powder.
pka :1.22±0.10(Predicted)
Density :1.763±0.06 g/cm3(Predicted)
solubility :PBS (pH 7.2): 2 mg/ml
form :White powder.
pka :1.22±0.10(Predicted)
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||
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Description
Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 μM and an IC50 value of 1mM for rat mGluR1α when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 μM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson’s disease, and the increased activity of mGluR implicated in fragile X syndrome.Related product price
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