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5652-28-8

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5652-28-8 Structure

5652-28-8 Structure
IdentificationBack Directory
[Name]

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
[CAS]

5652-28-8
[Synonyms]

2-AP3
Alanine, 3-phosphono-
2-Amino-3-phosphonopropionic acid
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
[Molecular Formula]

C3H8NO5P
[MDL Number]

MFCD00014350
[MOL File]

5652-28-8.mol
[Molecular Weight]

169.07
Chemical PropertiesBack Directory
[Boiling point ]

481.6±55.0 °C(Predicted)
[density ]

1.763±0.06 g/cm3(Predicted)
[form ]

White powder.
[pka]

1.22±0.10(Predicted)
Hazard InformationBack Directory
[Description]

Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 μM and an IC50 value of 1mM for rat mGluR1α when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 μM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson’s disease, and the increased activity of mGluR implicated in fragile X syndrome.
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