Epalrestat
|
- $5 - $1802
- Product name: Epalrestat
- CAS: 82159-09-9
- MF: C15H13NO3S2
- MW: 319.4
- EINECS:675-018-0
- MDL Number:MFCD00865484
- Synonyms:5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet ;e)-(e ;EPALRESTAT;(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid;AKOS BBS-00007767;OTAVA-BB BB7211260020;Epalrest;Epalrestat, 99.5%
59 prices
Selected condition：
Brand
- AHH
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- Arctom
- AstaTech
- Atlantic Research Chemicals
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 5mg
- 10MG
- 25MG
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- 10g
- 25g
- 100g
- 1gm:
- 5/ G
- 25/ G
- ManufacturerAHH
- Product numberAPI-1403
- Product descriptionEpalrestat 98%
- Packaging1g
- Price$910
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberH951
- Product descriptionEpalrestat
- Packaging10g
- Price$161
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA245255
- Product descriptionEpalrestat 95%
- Packaging100mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA245255
- Product descriptionEpalrestat 95%
- Packaging250mg
- Price$6
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA245255
- Product descriptionEpalrestat 95%
- Packaging1g
- Price$15
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA245255
- Product descriptionEpalrestat 95%
- Packaging5g
- Price$42
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA245255
- Product descriptionEpalrestat 95%
- Packaging10g
- Price$74
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA245255
- Product descriptionEpalrestat 95%
- Packaging25g
- Price$164
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA245255
- Product descriptionEpalrestat 95%
- Packaging100g
- Price$519
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002559
- Product descriptionEPALRESTAT 95.00%
- Packaging25MG
- Price$163.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002559
- Product descriptionEPALRESTAT 95.00%
- Packaging10MG
- Price$716.1
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002559
- Product descriptionEPALRESTAT 95.00%
- Packaging100MG
- Price$1686.3
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS491885
- Product descriptionEpalrestat 95%
- Packaging100mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS491885
- Product descriptionEpalrestat 95%
- Packaging250mg
- Price$6
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS491885
- Product descriptionEpalrestat 95%
- Packaging1g
- Price$15
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS491885
- Product descriptionEpalrestat 95%
- Packaging5g
- Price$42
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AHH | API-1403 | Epalrestat 98% | 1g | $910 | 2021-12-16 | Buy |
| AK Scientific | H951 | Epalrestat | 10g | $161 | 2021-12-16 | Buy |
| Ambeed | A245255 | Epalrestat 95% | 100mg | $5 | 2021-12-16 | Buy |
| Ambeed | A245255 | Epalrestat 95% | 250mg | $6 | 2021-12-16 | Buy |
| Ambeed | A245255 | Epalrestat 95% | 1g | $15 | 2021-12-16 | Buy |
| Ambeed | A245255 | Epalrestat 95% | 5g | $42 | 2021-12-16 | Buy |
| Ambeed | A245255 | Epalrestat 95% | 10g | $74 | 2021-12-16 | Buy |
| Ambeed | A245255 | Epalrestat 95% | 25g | $164 | 2021-12-16 | Buy |
| Ambeed | A245255 | Epalrestat 95% | 100g | $519 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002559 | EPALRESTAT 95.00% | 25MG | $163.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002559 | EPALRESTAT 95.00% | 10MG | $716.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002559 | EPALRESTAT 95.00% | 100MG | $1686.3 | 2021-12-16 | Buy |
| Arctom | AS491885 | Epalrestat 95% | 100mg | $5 | 2021-12-16 | Buy |
| Arctom | AS491885 | Epalrestat 95% | 250mg | $6 | 2021-12-16 | Buy |
| Arctom | AS491885 | Epalrestat 95% | 1g | $15 | 2021-12-16 | Buy |
| Arctom | AS491885 | Epalrestat 95% | 5g | $42 | 2021-12-16 | Buy |
Properties
Melting point :210-217 C
Boiling point :516.8±60.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :3.62±0.10(Predicted)
form :powder
color :yellow to orange
Merck :14,3605
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI :InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
InChIKey :CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES :S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S
Boiling point :516.8±60.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :3.62±0.10(Predicted)
form :powder
color :yellow to orange
Merck :14,3605
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI :InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
InChIKey :CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES :S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Aldose reductase, the first enzyme of the polyol pathway, converts glucose to sorbitol in the presence of NADPH. Increased aldose reductase expression, induced by hyperglycemia, has been associated with complications of diabetes, as it can create a metabolic imbalance in tissues dependent on insulin for the uptake of glucose. Epalrestat is a carboxylic acid-based inhibitor of aldose reductase (IC50 = 0.01-15 μM). At 10 nM, it can suppress high glucose-induced proliferation of vascular smooth muscle cells and at 100 nM it can prevent high glucose-induced intracellular NADH/NAD+ increase and membrane-bound protein kinase C activation. Epalrestat has been shown to reduce oxidative stress in type 2 diabetic patients, significantly decreasing lipid hydroperoxide levels in erythrocytes when administered at 150 mg/day.Related product price
- 5-Chloro-2-methyl-3(2H)-isothiazolone with 2-methyl-3(2H)-isothiazolone
$5-1080 - Kresoxim-methyl
$44-990 - Methyl acetate
$14-1334.03
Suppliers and manufacturers
Shanghai Joiny Pharmaceutical Co.,LTD
![(E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid](/ProductImageEN/2024-03/small/d400b5af-718c-49d8-b10c-5c8555592bef.png)
Alfa Chemistry
Shanghai Jinhuan Chemical CO.,LTD.
Beijing Cooperate Pharmaceutical Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
Hefei TNJ Chemical Industry Co.,Ltd.
Shanghai Zheyan Biotech Co., Ltd.
$0.00 /25kg
(E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid CAS:82159-09-9
(E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid CAS:82159-09-9
