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ChemicalBook >> CAS DataBase List >> LOXO-101

LOXO-101

LOXO-101 price.
  • $19 - $2841
  • Product name: LOXO-101
  • CAS: 1223403-58-4
  • MF: C21H22F2N6O2
  • MW: 428.44
  • EINECS:
  • MDL Number:MFCD28902192
  • Synonyms:LOXO-101;ARRY 470;(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;LOXO-101 (ARRY-470);CS-2322;LOXO101;LOXO 101; LOXO-101 Larotrectinib;LOXO-101 (ARRY-470,Larotrectinib)
Price67 Properties Safety Information Description
67 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
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  • Usbiological
Package
  • 10mM(1mLinDMSO)
  • 1mg
  • 5mg
  • 10.00mg
  • 10mg
  • 25.00mg
  • 25mg
  • 50.00mg
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • 5G
  • Manufactureraablocks
  • Product numberAA00171P
  • Product description(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98%
  • Packaging1mg
  • Price$19
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00171P
  • Product description(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98%
  • Packaging5mg
  • Price$34
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00171P
  • Product description(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98%
  • Packaging10mg
  • Price$42
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00171P
  • Product description(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98%
  • Packaging25mg
  • Price$53
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00171P
  • Product description(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98%
  • Packaging50mg
  • Price$68
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00171P
  • Product description(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98%
  • Packaging100mg
  • Price$103
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00171P
  • Product description(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98%
  • Packaging250mg
  • Price$174
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product descriptionLOXO-101 98%
  • Packaging100MG
  • Price$110
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product descriptionLOXO-101 98%
  • Packaging100MG
  • Price$110
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product description(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97%
  • Packaging25MG
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product descriptionLOXO-101 98%
  • Packaging25MG
  • Price$40
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product descriptionLOXO-101 98%
  • Packaging25MG
  • Price$40
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product description(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97%
  • Packaging5MG
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product descriptionLOXO-101 98%
  • Packaging5MG
  • Price$30
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product descriptionLOXO-101 98%
  • Packaging5MG
  • Price$30
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberH-8992
  • Product descriptionLOXO-101 98%
  • Packaging1G
  • Price$495
  • Updated2026-05-25
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00171P (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98% 1mg $19 2026-05-28 Buy
aablocks AA00171P (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98% 5mg $34 2026-05-28 Buy
aablocks AA00171P (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98% 10mg $42 2026-05-28 Buy
aablocks AA00171P (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98% 25mg $53 2026-05-28 Buy
aablocks AA00171P (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98% 50mg $68 2026-05-28 Buy
aablocks AA00171P (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98% 100mg $103 2026-05-28 Buy
aablocks AA00171P (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide 98% 250mg $174 2026-05-28 Buy
ACHEMBLOCK H-8992 LOXO-101 98% 100MG $110 2026-05-25 Buy
ACHEMBLOCK H-8992 LOXO-101 98% 100MG $110 2026-05-27 Buy
ACHEMBLOCK H-8992 (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97% 25MG $95 2021-12-16 Buy
ACHEMBLOCK H-8992 LOXO-101 98% 25MG $40 2026-05-25 Buy
ACHEMBLOCK H-8992 LOXO-101 98% 25MG $40 2026-05-27 Buy
ACHEMBLOCK H-8992 (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide 97% 5MG $30 2021-12-16 Buy
ACHEMBLOCK H-8992 LOXO-101 98% 5MG $30 2026-05-25 Buy
ACHEMBLOCK H-8992 LOXO-101 98% 5MG $30 2026-05-27 Buy
ACHEMBLOCK H-8992 LOXO-101 98% 1G $495 2026-05-25 Buy
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Properties

Density :1.55±0.1 g/cm3(Predicted)
storage temp. :RT
solubility :Soluble in DMSO (up to 5 mg/ml).
form :solid
pka :8.41±0.40(Predicted)
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

LOXO-101 is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC (IC50s = 2-20 nM). It is selective for TrkA, -B, and -C over a panel of 226 kinases at 1 μM. LOXO-101 inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = <100, <10, and <10 nM, respectively). In vivo, LOXO-101 (60 and 200 mg/kg) reduces tumor growth in a KM12 mouse xenograft model.

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