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ChemicalBook >> CAS DataBase List >> MAK-683

MAK-683

MAK-683 price.
  • $56 - $2400
  • Product name: MAK-683
  • CAS: 1951408-58-4
  • MF: C20H17FN6O
  • MW: 376.39
  • EINECS:-0
  • MDL Number:MFCD31630846
  • Synonyms:CPD 1111;MAK-683;EED inhibitor-1;MAK 683;MAK-683;MAK683;N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine;N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID;1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-;inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683
Price24 Properties Safety Information Description
24 prices
Selected condition：
Brand
  • aablocks
  • AK Scientific
  • American Custom Chemicals Corporation
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 2mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • Manufactureraablocks
  • Product numberAA01EO2R
  • Product descriptionN-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99%
  • Packaging10mg
  • Price$56
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EO2R
  • Product descriptionN-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99%
  • Packaging25mg
  • Price$95
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EO2R
  • Product descriptionN-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99%
  • Packaging50mg
  • Price$159
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EO2R
  • Product descriptionN-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99%
  • Packaging100mg
  • Price$271
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EO2R
  • Product descriptionN-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99%
  • Packaging250mg
  • Price$459
  • Updated2026-05-30
  • Buy
  • ManufacturerAK Scientific
  • Product number5985EG
  • Product descriptionEEDinhibitor-1
  • Packaging1mg
  • Price$187
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0005707
  • Product descriptionN-((5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL)-8-(2-METHYLPYRIDIN-3-YL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-5-AMINE 95.00%
  • Packaging5MG
  • Price$453.52
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth
  • Product numberBDD40858
  • Product descriptionMAK-683
  • Packaging25mg
  • Price$1375
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberBDD40858
  • Product descriptionMAK-683
  • Packaging10mg
  • Price$900
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberBDD40858
  • Product descriptionMAK-683
  • Packaging1mg
  • Price$900
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberBDD40858
  • Product descriptionMAK-683
  • Packaging2mg
  • Price$900
  • Updated2026-06-04
  • Buy
  • ManufacturerBiosynth
  • Product numberBDD40858
  • Product descriptionMAK-683
  • Packaging5mg
  • Price$900
  • Updated2026-06-04
  • Buy
  • ManufacturerCayman Chemical
  • Product number29316
  • Product descriptionMAK-683 ≥98%
  • Packaging1mg
  • Price$90
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number29316
  • Product descriptionMAK-683 ≥98%
  • Packaging5mg
  • Price$370
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number29316
  • Product descriptionMAK-683 ≥98%
  • Packaging10mg
  • Price$653
  • Updated2026-04-30
  • Buy
  • ManufacturerChemScene
  • Product numberCS-8054
  • Product descriptionMAK683 99.02%
  • Packaging100mg
  • Price$1370
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA01EO2R N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99% 10mg $56 2026-05-30 Buy
aablocks AA01EO2R N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99% 25mg $95 2026-05-30 Buy
aablocks AA01EO2R N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99% 50mg $159 2026-05-30 Buy
aablocks AA01EO2R N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99% 100mg $271 2026-05-30 Buy
aablocks AA01EO2R N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine 99% 250mg $459 2026-05-30 Buy
AK Scientific 5985EG EEDinhibitor-1 1mg $187 2021-12-16 Buy
American Custom Chemicals Corporation INB0005707 N-((5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL)-8-(2-METHYLPYRIDIN-3-YL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-5-AMINE 95.00% 5MG $453.52 2021-12-16 Buy
Biosynth BDD40858 MAK-683 25mg $1375 2026-06-04 Buy
Biosynth BDD40858 MAK-683 10mg $900 2026-06-04 Buy
Biosynth BDD40858 MAK-683 1mg $900 2026-06-04 Buy
Biosynth BDD40858 MAK-683 2mg $900 2026-06-04 Buy
Biosynth BDD40858 MAK-683 5mg $900 2026-06-04 Buy
Cayman Chemical 29316 MAK-683 ≥98% 1mg $90 2026-04-30 Buy
Cayman Chemical 29316 MAK-683 ≥98% 5mg $370 2026-04-30 Buy
Cayman Chemical 29316 MAK-683 ≥98% 10mg $653 2026-04-30 Buy
ChemScene CS-8054 MAK683 99.02% 100mg $1370 2026-06-04 Buy
Next Last

Properties

Density :1.47±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: 15 mg/ml
form :A solid
pka :2.70±0.12(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM.

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Suppliers and manufacturers

ShangHai Caerulum Pharma Discovery Co., Ltd. Bide Pharmatech Ltd. Shanghai Lollane Biological Technology Co.,Ltd. Shanghai YuanYe Biotechnology Co., Ltd. NanJing Xienuo bio Co.,Ltd. ShangHai Biochempartner Co.,Ltd Shanghai SuperLan Chemcial Technique Centre Amadis Chemical Company Limited Kaixin Chemical (Hong Kong) Limited Shanghai Biopharmaleader Co., Ltd.