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ChemicalBook >> CAS DataBase List >> Rhein

Rhein

$5 - $2120
Product name: Rhein
CAS: 478-43-3
MF: C15H8O6
MW: 284.22
EINECS:207-521-4
MDL Number:MFCD00009618
Synonyms:chrysazin-3-carboxylicacid ;monorhein ;rheicacid ;RHUBARB YELLOW;RHEIN;TIMTEC-BB SBB001152;1,8-DIHYDROXY-9,10-ANTHRAQUINONE-3-CARBOXYLIC ACID;1,8-dihydroxy-3-carboxyanthraquinone

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aablocks
ACHEMBLOCK
AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Arctom
AvaChem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
Chem-Impex
ChemScene
Chemtos
Crysdot
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Matrix Scientific
Medical Isotopes, Inc.
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE ≥98%
Packaging50mg
Price$10
Updated2026-05-28
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging100mg
Price$11
Updated2026-05-28
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE ≥98%
Packaging250mg
Price$11
Updated2026-05-28
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging1g
Price$15
Updated2026-05-28
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging5g
Price$33
Updated2026-05-28
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging25g
Price$102
Updated2026-05-28
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging100g
Price$359
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberX191876
Product description4,5-Dihydroxyanthraquinone-2-carboxylic acid 95.00%
Packaging25G
Price$105
Updated2026-05-27
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ManufacturerAK Scientific
Product numberC432
Product descriptionRhein
Packaging1g
Price$364
Updated2021-12-16
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ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging25g
Price$188
Updated2021-12-16
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ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging5g
Price$58
Updated2021-12-16
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ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging25mg
Price$5
Updated2021-12-16
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ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging100mg
Price$6
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging250mg
Price$9
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging1g
Price$19
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging100g
Price$548
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE ≥98%	50mg	$10	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	100mg	$11	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE ≥98%	250mg	$11	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	1g	$15	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	5g	$33	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	25g	$102	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	100g	$359	2026-05-28	Buy
ACHEMBLOCK	X191876	4,5-Dihydroxyanthraquinone-2-carboxylic acid 95.00%	25G	$105	2026-05-27	Buy
AK Scientific	C432	Rhein	1g	$364	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	25g	$188	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	5g	$58	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	25mg	$5	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	100mg	$6	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	250mg	$9	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	1g	$19	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	100g	$548	2021-12-16	Buy

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Properties

Melting point :≥300 °C (lit.)
Boiling point :346.72°C (rough estimate)
Density :1.3269 (rough estimate)
refractive index :1.4413 (estimate)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :3.17±0.20(Predicted)
color :Yellow to Dark Orange
Water Solubility :<0.1 g/100 mL at 17 ºC
λmax :432nm(MeOH)(lit.)
Merck :14,8176
BRN :2222155
Stability :Hygroscopic
Cosmetics Ingredients Functions :ANTIMICROBIAL
InChI :1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)
InChIKey :FCDLCPWAQCPTKC-UHFFFAOYSA-N
SMILES :OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
LogP :4.290 (est)
CAS DataBase Reference :478-43-3(CAS DataBase Reference)
EPA Substance Registry System :2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (478-43-3)

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α, IL-1β, and HMBG1 expression. Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic β-cell apoptosis. It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.

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Suppliers and manufacturers

Wuhan ShuEr Biology Technology Co.,Ltd

$20.00
Rhein CAS:478-43-3

Hebei Zhuanglai Chemical Trading Co Ltd

$150.00
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career henan chemical co

$1.00
Rhein CAS: 478-43-3

Henan Tianfu Chemical Co.,Ltd.

Nanjing ChemLin Chemical Industry Co., Ltd.

Shanghai Zheyan Biotech Co., Ltd.

Shaanxi Yikanglong Biotechnology Co., Ltd.

Chengdu Biopurify Phytochemicals Ltd.

Xiamen AmoyChem Co., Ltd

Xi'an Kono chem co., Ltd.,

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Rhein

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