SirReal2
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- $37 - $900
- Product name: SirReal2
- CAS: 709002-46-0
- MF: C22H20N4OS2
- MW: 420.55
- EINECS:
- MDL Number:MFCD04173051
- Synonyms:SirReal2;Acetamide,2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-;2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide;2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide;SirReal2 >=98% (HPLC);Sirtuin,Inhibitor,inhibit,SirReal2,SirReal 2,SirReal-2;2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide;SirReal2, 10 mM in DMSO
25 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 50
- 2x5mg
- 25mg
- 50mg
- 100mg
- 250mg
- 5 mg
- 25 mg
- ManufacturerAK Scientific
- Product number4698CE
- Product description2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
- Packaging10mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6016
- Product descriptionSirReal2
- Packaging25mg
- Price$279
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6016
- Product descriptionSirReal2
- Packaging5mg
- Price$75
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6016
- Product descriptionSirReal2
- Packaging100mg
- Price$679
- Updated2026-05-06
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2453
- Product descriptionSirReal2 98%
- Packaging2x5mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging10mg
- Price$178
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging10mg
- Price$196
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging5mg
- Price$128
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging1mg
- Price$41
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging50mg
- Price$793
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18116
- Product descriptionSirReal2 ≥98%
- Packaging50mg
- Price$873
- Updated2026-04-30
- Buy
- ManufacturerChemScene
- Product numberCS-0019744
- Product descriptionSirReal2 >99.0%
- Packaging10mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0019744
- Product descriptionSirReal2 >99.0%
- Packaging5mg
- Price$375
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN19216
- Product descriptionSirReal2
- Packaging10mg
- Price$605
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4698CE | 2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide | 10mg | $336 | 2021-12-16 | Buy |
| ApexBio Technology | B6016 | SirReal2 | 25mg | $279 | 2026-05-06 | Buy |
| ApexBio Technology | B6016 | SirReal2 | 5mg | $75 | 2026-05-06 | Buy |
| ApexBio Technology | B6016 | SirReal2 | 100mg | $679 | 2026-05-06 | Buy |
| Axon Medchem | Axon2453 | SirReal2 98% | 2x5mg | $165 | 2021-12-16 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 10mg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 10mg | $196 | 2026-04-30 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 50mg | $793 | 2024-03-01 | Buy |
| Cayman Chemical | 18116 | SirReal2 ≥98% | 50mg | $873 | 2026-04-30 | Buy |
| ChemScene | CS-0019744 | SirReal2 >99.0% | 10mg | $650 | 2021-12-16 | Buy |
| ChemScene | CS-0019744 | SirReal2 >99.0% | 5mg | $375 | 2021-12-16 | Buy |
| CSNpharm | CSN19216 | SirReal2 | 10mg | $605 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form :A crystalline solid
color :Off-white to light yellow
InChI :1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27)
InChIKey :MENNDDDTIIZDDN-UHFFFAOYSA-N
SMILES :CC1=NC(SCC(NC2=NC=C(S2)CC3=CC=CC4=C3C=CC=C4)=O)=NC(C)=C1
solubility :DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form :A crystalline solid
color :Off-white to light yellow
InChI :1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27)
InChIKey :MENNDDDTIIZDDN-UHFFFAOYSA-N
SMILES :CC1=NC(SCC(NC2=NC=C(S2)CC3=CC=CC4=C3C=CC=C4)=O)=NC(C)=C1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.Related product price
- 2-Amino-4,6-dimethylpyrimidine
$5-860 - Acetamide
$13-950