TMC-207
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- $40 - $2400
- Product name: TMC-207
- CAS: 843663-66-1
- MF: C32H31BrN2O2
- MW: 555.5
- EINECS:1308068-626-2
- MDL Number:
- Synonyms:TMC-207;R 207910;Bedaquiline(R 207910,TMC 207);Bedaquiline (TMC-207);(αS,βR)-Bedaquiline ;bedaquinline;(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol;Bedaquiline D6
33 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- AvaChem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 10mM(in 1mL DMSO)
- 1mg
- 2mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number9709BB
- Product description(2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol
- Packaging2mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0010350
- Product descriptionTMC-207 95.00%
- Packaging5MG
- Price$502.71
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3492
- Product descriptionBedaquiline
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3492
- Product descriptionBedaquiline
- Packaging10mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3492
- Product descriptionBedaquiline
- Packaging10mM(in 1mL DMSO)
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3492
- Product descriptionBedaquiline
- Packaging50mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0131
- Product descriptionBedaquiline
- Packaging2mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0131
- Product descriptionBedaquiline
- Packaging5mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0131
- Product descriptionBedaquiline
- Packaging10mg
- Price$196
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3375B
- Product descriptionBedaquiline
- Packaging5mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3375B
- Product descriptionBedaquiline
- Packaging10mg
- Price$69
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3375B
- Product descriptionBedaquiline
- Packaging25mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3375B
- Product descriptionBedaquiline
- Packaging100mg
- Price$229
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3375B
- Product descriptionBedaquiline
- Packaging1g
- Price$549
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB46540
- Product description(1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
- Packaging2mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFB46540
- Product description(1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 9709BB | (2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol | 2mg | $104 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010350 | TMC-207 95.00% | 5MG | $502.71 | 2021-12-16 | Buy |
| ApexBio Technology | B3492 | Bedaquiline | 5mg | $55 | 2021-12-16 | Buy |
| ApexBio Technology | B3492 | Bedaquiline | 10mg | $75 | 2021-12-16 | Buy |
| ApexBio Technology | B3492 | Bedaquiline | 10mM(in 1mL DMSO) | $80 | 2021-12-16 | Buy |
| ApexBio Technology | B3492 | Bedaquiline | 50mg | $290 | 2021-12-16 | Buy |
| Apolloscientific | BISN0131 | Bedaquiline | 2mg | $95 | 2021-12-16 | Buy |
| Apolloscientific | BISN0131 | Bedaquiline | 5mg | $138 | 2021-12-16 | Buy |
| Apolloscientific | BISN0131 | Bedaquiline | 10mg | $196 | 2021-12-16 | Buy |
| AvaChem | 3375B | Bedaquiline | 5mg | $49 | 2021-12-16 | Buy |
| AvaChem | 3375B | Bedaquiline | 10mg | $69 | 2021-12-16 | Buy |
| AvaChem | 3375B | Bedaquiline | 25mg | $109 | 2021-12-16 | Buy |
| AvaChem | 3375B | Bedaquiline | 100mg | $229 | 2021-12-16 | Buy |
| AvaChem | 3375B | Bedaquiline | 1g | $549 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB46540 | (1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol | 2mg | $40 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB46540 | (1R,2S)-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol | 5mg | $75 | 2021-12-16 | Buy |
Properties
Melting point :104 °C
Boiling point :702.7±60.0 °C(Predicted)
Density :1.322±0.06 g/cm3(Predicted)
storage temp. :Room temperature
solubility :Soluble in DMSO (10 mg/ml)
form :solid
pka :13.05±0.29(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference :843663-66-1
Boiling point :702.7±60.0 °C(Predicted)
Density :1.322±0.06 g/cm3(Predicted)
storage temp. :Room temperature
solubility :Soluble in DMSO (10 mg/ml)
form :solid
pka :13.05±0.29(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference :843663-66-1
Safety Information
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Description
In December 2012, the US FDA approved bedaquiline as part of combination therapy for the treatment of multi-drug resistant tuberculosis (MDRTB). Bedaquiline is the first drug approved for MDR-TB and is the first approval from a new class of antituberculosis agents in the past 40 years. Due to the high unmetmedical need for treating MDR-TB, the FDA granted bedaquiline accelerated approval based on Phase II results, providing patients access to the drug while additional clinical studies are carried out. Bedaquiline (also known as TMC207 and R207910) is a diarylquinoline that was discovered from a high-throughput, whole-cell screening strategy with Mycobacterium smegmatis used as a surrogate for M. tuberculosis. Bedaquiline is a single enantiomer of an initial screening hit. Bedaquiline has potent and selective activity against mycobacteria, and is active against both drug-sensitive and drug-resistant M. tuberculosis. The mechanism of action of bedaquiline is unique amongst anti-TB drugs and involves inhibition of mycobacterial ATP synthase; it is not active against human ATP synthase. Bedaquiline has in vivo activity in numerous preclinical models of TB infection, alone and in combination with other anti-TB agents, and has bactericidal activity in established TB infection models. Bedaquiline is synthesized in five steps from 3-phenylpropionic acid and para-bromoaniline. Following amide formation, treatment with POCl3 and DMF under Vilsmeier–Hack conditions gave a 2-chloroquinoline product. Treatment with sodium methoxide, followed by condensation with 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one, and separation of isomers gave bedaquiline.Related product price
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