N,N,N',N'-四(2-吡啶甲基)乙二胺
中文名称 | N,N,N',N'-四(2-吡啶甲基)乙二胺 |
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中文同义词 | N,N,N',N'-4(2-吡啶甲基)乙二胺;N,N,N',N'-四(2-吡啶甲基)乙二胺,室温保存即可;1,2-乙烷二胺, N,N,N',N'-四(2-吡啶基甲基)-;N,N,N',N'-四(2-吡啶甲基)乙二胺;N,N,N',N'-四(2-吡啶甲基)乙二胺;N,N,N',N'-四-(2-吡啶基甲基)乙二胺;N,N,N',N'-四KIS-(2-吡啶基甲基)乙二胺;N,N,N',N'-四-(2-吡啶基甲基)乙二 |
英文名称 | TPEN |
英文同义词 | N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-Ethanediamine;TPEN;1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-;1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-, (oc-6-11)-;N1,N1,N2,N2-tetrakis(pyridin-2-ylMethyl)ethane-1,2-diaMine;N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine |
CAS号 | 16858-02-9 |
分子式 | C26H28N6 |
分子量 | 424.54 |
EINECS号 | |
相关类别 | 杂环化合物;合成材料中间体;聚合试剂;其它;Heterocycles;Apoptosis;Aromatics;Chelating Agents & Ligands;Inhibitors;Apoptosis Inducers |
Mol文件 | 16858-02-9.mol |
结构式 |
N,N,N',N'-四(2-吡啶甲基)乙二胺 性质
熔点 | 110-112 °C |
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沸点 | 530.56°C (rough estimate) |
密度 | 1.3893 (rough estimate) |
折射率 | 1.4570 (estimate) |
储存条件 | Sealed in dry,2-8°C |
溶解度 | 溶于DMSO(高达10mg/ml)。 |
酸度系数(pKa) | 5.19±0.12(Predicted) |
形态 | 棕褐色固体 |
颜色 | 灰白色或棕褐色 |
BRN | 4211982 |
稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
CAS 数据库 | 16858-02-9(CAS DataBase Reference) |
Target | Value |
NO
() |
Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. TPEN, a cell-permeable chelator for heavy metal cations with a low affinity for Ca 2+ . In cells stimulated with 10 or 30 μM cadmium chloride, the addition of TPEN at 3 hr after exposure significantly decreases the elevated fura-2 fluorescence ratio to the basal levels within 10 min (119.6±2.4% or 109±1.5% decrease in ΔRatio (F340/F380) induced by 10 or 30 μM cadmium chloride, respectively), suggesting that a cadmium chloride-induced increase in the fura-2 fluorescence ratio is dependent on an increase in intracellular heavy metal cations but not intracellular Ca 2+ . TPEN is a metal chelator, which targets colon cancer cells through redox cycling of copper. TPEN reduces cell viability in a dose- and time-dependent manner. TPEN-induced cell death is also dependent on the redox cycling of copper since the copper chelator neocuproine inhibited DNA damage and reduced pChk1, γ-H2AX, and ATM protein expression. Cell death by low TPEN concentrations, involved ATM/ATR signaling in all 3 cell lines, since pre-incubation with specific inhibitors of ATM and DNA-PK led to the recovery of cells from TPEN-induced DNA damage.
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | J64206 | N,N,N',N'-四kis-(2-吡啶基甲基)乙二胺 N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine | 16858-02-9 | 100mg | 1862元 |
2024/08/19 | J64206 | N,N,N',N'-四kis-(2-吡啶基甲基)乙二胺 N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine | 16858-02-9 | 300mg | 4657元 |