N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯
中文名称 | N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯 |
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中文同义词 | N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯;苯乙酰甘氨酸乙酯;N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯生产厂家;N-(1-(苯基乙酰基)-L-脯氨酰) 甘氨酸乙酯 157115-85-0;N-(1-苯基乙酰基)-L-脯氨酰胺甘氨酸乙酯;NOOPEPTN-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯;N-(1-(苯基乙酰基)-L-脯氨酰)甘氨;N-(1-(苯基乙酰基) --脯氨酚 |
英文名称 | Noopept |
英文同义词 | Noopept;ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate;(S)-ethyl 2-(1-(2-phenylacetyl)pyrrolidine-2-carboxaMido)acetate;SGS 111;SGS111;SGS-111;1-(2-Phenylacetyl)-L-prolylglycine Ethyl Ester;skype |
CAS号 | 157115-85-0 |
分子式 | C17H22N2O4 |
分子量 | 318.37 |
EINECS号 | 1592732-453-0 |
相关类别 | 抑制剂;营养品原料;食品添加剂;膜转运/离子通道;医药中间体;营养剂;化合物;原料药API;pharmaceutical intermediate and medicine grade;食品添加;原料;有机中间体;合成材料中间体;产品;API |
Mol文件 | 157115-85-0.mol |
结构式 |
N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯 性质
熔点 | 94.0 to 98.0 °C |
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沸点 | 547.3±50.0 °C(Predicted) |
密度 | 1.202±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 溶于DMSO(高达25mg/ml) |
形态 | 粉末 |
酸度系数(pKa) | 13.41±0.20(Predicted) |
颜色 | 白色至米色 |
旋光性 (optical activity) | [α]/D -115 to -125°, c = 0.5 in chloroform-d |
稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 中的溶液可在 -20°C 下保存长达 2 个月。 |
InChI | InChI=1S/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1 |
InChIKey | PJNSMUBMSNAEEN-AWEZNQCLSA-N |
SMILES | C(OCC)(=O)CNC(=O)[C@@H]1CCCN1C(CC1=CC=CC=C1)=O |
CAS 数据库 | 157115-85-0 |
N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯的商品名NOOPEPT,作为治疗肥胖、酒精依赖性退化或中毒性损伤等疾病。
Omberacetam (GVS-111) 是可作为膳食补充剂的多肽。Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM) [1]. GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action [2].
N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit [3]. GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions [4]. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively) [5].
安全信息
RTECS号 | MC0814400 |
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海关编码 | 29339900 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-17456 | N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯 Omberacetam | 157115-85-0 | 5mg | 400元 |
2024/08/19 | HY-17456 | N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯 Omberacetam | 157115-85-0 | 10mM * 1mLin DMSO | 440元 |