依匹斯汀
中文名称 | 依匹斯汀 |
---|---|
中文同义词 | 依匹斯汀;依匹斯汀碱;3-氨基-9,13-二氢-1H-二苯并[c,f]咪唑并[1,5-a]氮杂卓;依匹斯汀碱/依匹斯汀/;9,13B-二氢-1H-二苯并[C,F]咪唑并[1,5-A]氮杂卓-3-胺;化合物 EPINASTINE;甲醇中依匹斯汀标准溶液 |
英文名称 | Epinastine |
英文同义词 | 3-amino-9,13b-dihydro-1h-dibenz[c,f]imidazo[1,5-a]azepine;EPINASTINE;EPINASTINE BASE;9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine;Apinastine Base;3-Amino-9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine;CS-1366;ELESTAT;WAL801 |
CAS号 | 80012-43-7 |
分子式 | C16H15N3 |
分子量 | 249.31 |
EINECS号 | 616-785-3 |
相关类别 | 医药中间体;对照品-杂质对照品;标准品;中药对照品;医药原料 |
Mol文件 | 80012-43-7.mol |
结构式 |
依匹斯汀 性质
熔点 | 205-208° |
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沸点 | 428.0±55.0 °C(Predicted) |
密度 | 1.32±0.1 g/cm3(Predicted) |
储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
溶解度 | DMSO:≥ 50 mg/mL (200.55 mM);水:< 0.1 mg/mL(不溶) |
酸度系数(pKa) | 11.2(at 25℃) |
形态 | 固体 |
颜色 | 白色至米白色 |
CAS 数据库 | 80012-43-7(CAS DataBase Reference) |
Epinastine is able to displace specific [
3
H]NC-5Z binding at low concentrations in the locust nervous tissue. Epinastine binds to the honey bees neuronal octopamine receptor with K
i
of 1.1 nM. Epinastine antagonises octopamine-induced cAMP formation in the insect brain.
Epinastine causes an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine is similarly effective in inhibiting compound 48/80-induced histamine release not only from isolated rat peritoneal mast cells but also from rat mesenterial pieces. Epinastine is effective in inhibiting not only Ca
2+
uptake into lung mast cells in actively sensitized guinea pigs but also Ca
2+
release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance P.
Epinastine shows a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases.
Epinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. Epinastine inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-B0640 | 依匹斯汀 Epinastine | 80012-43-7 | 50mg | 750元 |
2024/08/19 | HY-B0640 | 依匹斯汀 Epinastine | 80012-43-7 | 10mM * 1mLin DMSO | 825元 |