1,8-二羟基蒽醌
中文名称 | 1,8-二羟基蒽醌 |
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中文同义词 | 1,8-二羟基-9,10-蒽二酮;丹蒽醌;1,8-蒽醌二酚;以斯替净;1,8-二羥蒽醌;金黃異茜素;1,8-二羟基蒽醌/丹蒽醌;1,8-二羟基蒽醌,95% |
英文名称 | 1,8-Dihydroxyanthraquinone |
英文同义词 | NSC 38626;NSC 646568;NSC 7210;Danthron 1,8-Dihydroxyanthraquinone Istizine;1,4,5,8-tetroxyantraquinone;Dionone;Dorbane;Dorbanex |
CAS号 | 117-10-2 |
分子式 | C14H8O4 |
分子量 | 240.21 |
EINECS号 | 204-173-5 |
相关类别 | 中药对照品;对照品、标准品、植物单体;有机砌块;植物提取物;对照品;医药中间体;酮;标准品;通用试剂;小分子抑制剂;小分子抑制剂,天然产物;有机化工;医药原料;有机原料;提取物;化学试剂;中间体;分析试剂标准品;生化试剂-其他化学试剂;有机化工原料;有机化工原料;Intermediates of Dyes and Pigments;Anthraquinones;Hydroxyanthraquinones;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Aloe Vera;Building Blocks;C13 to C14;Carbonyl Compounds;Chemical Synthesis;Ketones;Nutrition Research;Organic Building Blocks;Phytochemicals by Plant (Food/Spice/Herb);DORBANE;Inhibitors;标准品 -中药标准品;化工原料;化工原料-1827181813;其它天然产物;染料;标准品,对照品;bc0001 |
Mol文件 | 117-10-2.mol |
结构式 |
1,8-二羟基蒽醌 性质
熔点 | 191-193 °C (lit.) |
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沸点 | 342.92°C (rough estimate) |
密度 | 1.3032 (rough estimate) |
折射率 | 1.5430 (estimate) |
闪点 | >200°C |
储存条件 | Sealed in dry,2-8°C |
溶解度 | 溶于热乙酸中呈现微浑浊 |
形态 | 粉末 |
酸度系数(pKa) | 6.27±0.20(Predicted) |
颜色 | 橙棕色或棕色 |
水溶解性 | insoluble |
Merck | 14,2815 |
BRN | 2054727 |
LogP | 4.570 (est) |
CAS 数据库 | 117-10-2(CAS DataBase Reference) |
(IARC)致癌物分类 | 2B (Vol. 50) 1990 |
NIST化学物质信息 | 1,8-Dihydroxyanthraquinone(117-10-2) |
EPA化学物质信息 | Danthron (117-10-2) |
AMPK
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Danthron (0.1, 1, and 10 μM) dose-dependently promotes the phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in both HepG2 and C2C12 cells. Meanwhile, Danthron treatment significantly reduces the lipid synthesis related sterol regulatory element-binding protein 1c (SREBP1c) and fatty acid synthetase (FAS) gene expressions, and the total cholesterol (TC) and triglyceride (TG) levels. In addition, Danthron treatment efficiently increases glucose consumption. Danthron effectively reduces intracellular lipid contents and enhances glucose consumption in vitro via activation of AMPK signaling pathway. 10 μM Danthron/24 h is safe for HepG2 cells. With 80% confluence, HepG2 cells are incubated with Danthron (0.1-10 μM) in FBS-Free media for 8 h. Subsequently, cells are harvested for Western blot assay. Danthron increases the p-AMPK protein in a dose-dependent manner, and no changes in t-AMPK protein are observed. Danthron inhibits 9-cis retinoic acid (9cRA)-induced retinoic X receptor α (RXRα) transactivation by IC 50 at 0.11 μM. To further clarify the stoichimetric ratio of Danthron binding to RXRα-ligand-binding domain (LBD), isothermal titration calorimetry (ITC) experiment is performed. The K D value of Danthron binds to RXRα-LBD by ITC experiment is determined at 7.5 μM.
Danthron functions as an insulin sensitizer in vivo. Danthron improves insulin sensitivity in diet-induced obese (DIO) mice. The insulin tolerance test result shows that Danthron (5 mg/kg) treated diet-induced obesity mice exhibit lower glucose levels after insulin challenge, compared with the control vehicle-treated group.
安全信息
危险品标志 | Xn |
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危险类别码 | 40 |
安全说明 | 36/37-36-22 |
危险品运输编号 | 2811 |
WGK Germany | 1 |
RTECS号 | CB6650000 |
TSCA | Yes |
危险等级 | IRRITANT |
海关编码 | 29146990 |
毒害物质数据 | 117-10-2(Hazardous Substances Data) |
毒性 | LD50 orally in mice: <7 g/kg (Case) |
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