羟基嘌呤
| 中文名称 | 羟基嘌呤 |
|---|---|
| 中文同义词 | 1H-吡唑并[3,4-D]嘧啶-4,6(5H,7H)-二酮;4,6-二羟基吡唑并[3,4-D]嘧啶;4,6-二羟基吡唑啉[3,4-D]嘧啶, 98+%;奥昔嘌醇;氧嘌醇;氧嘌呤醇;4,6-二羟基吡唑啉[3,4-D]嘧啶;羟基嘌呤 |
| 英文名称 | Oxipurinol |
| 英文同义词 | 4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine, 98+%;4,6-Dihydropyrazolo Pyrimidine;4,6-Dihydroxypyrazolo[3,4-d]pyrimidine,99%;4,6-Dihydroxypyrazolo[3,4-d]pyriMidine (Oxypurinol);OXYPURINOL;OXIPURINOL;4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine;4,6-Dioxopyrazolo[3,4-d]pyrimidine |
| CAS号 | 2465-59-0 |
| 分子式 | C5H4N4O2 |
| 分子量 | 152.11 |
| EINECS号 | 219-570-9 |
| 相关类别 | 小分子抑制剂;对照品;Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Bases & Related Reagents;Pyridines, Pyrimidines, Purines and Pteredines;Nucleotides and Nucleosides;Nucleotides;Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides |
| Mol文件 | 2465-59-0.mol |
| 结构式 |  |
羟基嘌呤 性质
| 熔点 | 300 °C |
|---|---|
| 沸点 | 274.55°C (rough estimate) |
| 密度 | 1.637 |
| 折射率 | 1.8500 (estimate) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 溶于二甲基亚砜。 |
| 酸度系数(pKa) | pKa 7.7 (Uncertain) |
| 形态 | 粉末 |
| 颜色 | 浅黄色 |
| BRN | 139956 |
| 稳定性 | 具有吸湿性 |
| CAS 数据库 | 2465-59-0(CAS DataBase Reference) |
| EPA化学物质信息 | Oxypurinol (2465-59-0) |
Oxopurinol (Oxipurinol) 是 Allopurinol 的主要活性代谢产物，是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂。Oxipurinol 可用于调节血尿酸水平，有潜力用于痛风的研究。
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Human Endogenous Metabolite
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Allopurinol is rapidly metabolized (half-life approximately 1 h) to its active metabolite oxypurinol. Oxypurinol is an inhibitor of xanthine oxidoreductase and has a considerably longer elimination half-life (approximately 23 h).
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