3-甲基硫代丙酸
中文名称 | 3-甲基硫代丙酸 |
---|---|
中文同义词 | 3-(甲基硫代)丙酸,97%;3-甲基硫代丙酸;3-(甲硫基)丙酸;3-METHYLTHIOPROPIONATE|||3-甲基硫代丙酸|||4-THIAPENTANOIC ACID|||3-METHYLSULFANYLPROPIONIC ACID;舒更葡糖钠杂质59 |
英文名称 | 3-METHYLTHIOPROPIONIC ACID |
英文同义词 | 3-(Methylsulfanyl)propanoic acid;4-Thiapentanoic acid;Propanoic acid, 3-(methylthio)-;Propionic acid, 3-(methylthio)-;3-METHYTHIOPROPIONIC ACID;3-METHYLTHIO PROPIONATE;3-METHYLTHIOPROPIONIC ACID;3-METHYLMERCAPTOPROPIONIC ACID |
CAS号 | 646-01-5 |
分子式 | C4H8O2S |
分子量 | 120.17 |
EINECS号 | 211-460-9 |
相关类别 | 硫化合物;医药中间体;食品添加剂;羧酸 |
Mol文件 | 646-01-5.mol |
结构式 |
3-甲基硫代丙酸 性质
熔点 | 16°C |
---|---|
沸点 | 130°C 2mm |
密度 | 1.160 |
折射率 | 1.4884 |
闪点 | 130°C/15mm |
储存条件 | Store at -20°C |
形态 | 粉末至块状至透明液体 |
酸度系数(pKa) | 4.29±0.10(Predicted) |
颜色 | 白色或无色至浅黄色 |
气味 (Odor) | 甜硫磺味 |
水溶解性 | Water : 25 mg/mL (208.04 mM) |
BRN | 1743054 |
LogP | 0.458 (est) |
Human Endogenous Metabolite
|
Methionine has consistently been shown to be the most toxic amino acid in experiments devised to assess the relative toxicity of dietary amino acids. 3-methylthiopropionate is an intermediate in methionine catabolism in rat and monkey liver in vitro . This pathway appears to account for a major portion of methionine oxidation in vitro . Cultures of Streptomyces lincolnensis accumulated 3-methylthioacrylic acid in amounts directly related to the concentration of methionine in the medium. The first intermediate in the pathway may be the keto acid, which is then oxidatively decarboxylated to 3-methylthiopropionic acid. The purified 3-MTPA has antifungal activity in assays using F. oxysporum as a model fungus. Daily measurements of shoot and root length shows severe inhibition of seed germination and root and shoot development at concentrations above 12mg for partially purified extracts. 3-methylthiopropionic acid ethyl ester possesses potential anticarcinogenic properties by inducing differentiation in well-differentiated colon cancer cells. Treatment of RCM-1 cells for 4 days with 3-methylthiopropionic acid ethyl ester between the doses of 0.25 and 2 mM progressively increases the percent area occupied by duct structures relative to the control, and also induces an increase in the number and the maximum diameter of the ducts in each culture plate.
安全信息
危险类别码 | 34 |
---|---|
安全说明 | 26-36/37/39 |
危险品运输编号 | 3265 |
危险等级 | 8 |
包装类别 | II |
海关编码 | 29309090 |