乳酸甲氧苄啶
中文名称 | 乳酸甲氧苄啶 |
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中文同义词 | 乳酸甲氧苄啶 1G;2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶乳酸盐;甲氧苄啶 乳酸盐;乳酸三甲氧苄氨嘧啶;甲氧苄氨嘧啶乳酸盐;乳酸甲氧苄啶;乳酸甲氧苄氨嘧啶;TRIMETHOPRIM LACTATE SALT 乳酸甲氧苄啶 |
英文名称 | Trimethoprim lactate salt |
英文同义词 | 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt;TRIMETHOPRIM LACTATE;TRIMETHOPRIM LACTATE SALT;TRIMETHOPRIM LACTIC ACID;lactic acid, compound with 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine (1:1);5-(3,4,5-triMethoxybenzyl)pyriMidine-2,4-diaMine 2-hydroxypropanoate;Lactic triMethopriM;Trimethoprim lactate, >=99% |
CAS号 | 23256-42-0 |
分子式 | C17H24N4O6 |
分子量 | 380.4 |
EINECS号 | 245-533-1 |
相关类别 | 抗生素;中间体 Intermediate;兽药;饲料添加剂;医药原料药;兽药原料;医药原料;抗生素类;化合物:原料药;生化试剂;医药化工类;化学试剂;中间体;原料中间体-原料药;原料药;原料药;农用兽用原料;医用原料;医药、农药及染料中间体;兽药化工;化学试剂-兽用原料;原料;通用生化试剂-抗生素;兽用原料;化学试剂 |
Mol文件 | 23256-42-0.mol |
结构式 |
乳酸甲氧苄啶 性质
熔点 | 170 - 172°C |
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储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
溶解度 | H2O:可溶,20mg/mL |
形态 | 粉末 |
颜色 | 白色 |
水溶解性 | Soluble in water |
CAS 数据库 | 23256-42-0(CAS DataBase Reference) |
Dihydrofolate reductase
Bacteria
Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF).
Trimethoprim causes protein aggregation and induction of main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim presence leads to protein misfolding. Trimethoprim causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B are most efficiently induced by Trimethoprim and coaggregates with the insoluble proteins. Upon folate stress, deletion of the delta ibpA/B operon resulted in increased protein aggregation but does not influence cell viability.
In intraperitoneal infections in mice, the CD 50 values for Trimethoprim alone against H. influenzae , S. pneumoniae , E. coli and N. meningitidis , is 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively.
安全信息
危险品标志 | T |
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危险类别码 | 23/24/25-43-61 |
安全说明 | 22-36/37/39-45-53 |
危险品运输编号 | UN 2811 |
WGK Germany | 3 |
危险等级 | 6.1(b) |
包装类别 | III |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-B0510C | 乳酸甲氧苄啶 Trimethoprim lactate | 23256-42-0 | 500mg | 500元 |
2024/08/19 | HY-B0510C | 乳酸甲氧苄啶 Trimethoprim lactate | 23256-42-0 | 10mM * 1mLin DMSO | 550元 |