苯唑青霉素钠
中文名称 | 苯唑青霉素钠 |
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中文同义词 | 安迪灵;苯唑青;新青Ⅱ号;新青霉素;青霉素 P-12 钠盐;苯唑西林钠;苯甲异噁唑青霉素钠;新青霉素II |
英文名称 | Oxacillin sodium monohydrate |
英文同义词 | OXACILLIN NA;OXACILLIN SODIUM SALT HYDRATE VETRANAL,;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-diMethyl-6-[[(5-Methyl-3-phenyl-4-isoxazolyl)carbonyl]aMino]-7-oxo-,sodiuM salt, hydrate (1:1:1), (2S,5R,6R)-;Oxacillin sod;Oxacillin Sodium Salt (2S,5R,6R)-3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, sodium salt, hydrate (1:1:1);5-Methyl-3-phenyl-4-isoxazol penicillin sodium monohydrate;Oxacillin sodium monohydrate |
CAS号 | 7240-38-2 |
分子式 | C19H20N3NaO6S |
分子量 | 441.43 |
EINECS号 | 629-150-0 |
相关类别 | 青霉素类;小分子抑制剂,天然产物;医药原料;其它试剂;抗生素及抗病毒;抗生素;医药化工类;医药原料药;Antibiotics for Research and Experimental Use;beta-Lactams (Antibiotics for Research and Experimental Use);Biochemistry;beta-Lactam StructureEPA;1694 Pharmaceuticals&Personal Care Products;Alphabetic;Stains and Dyes;Stains&Dyes, A to;原料药;医药、农药及染料中间体;生化试剂;化学试剂;医用原料;通用生化试剂-抗生素;兽药原料;对照品;Antibiotics;BactericidalAntibiotics;Chemical Structure;NeatsAnalytical Standards;O;Principle;Peptide Synthesis/Antibiotics;Inhibitors |
Mol文件 | 7240-38-2.mol |
结构式 |
苯唑青霉素钠 性质
熔点 | 188 C |
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沸点 | 687℃ |
比旋光度 | D20 +201° (c = 1 in water) |
折射率 | 205 ° (C=1, H2O) |
闪点 | >110°(230°F) |
储存条件 | Inert atmosphere,2-8°C |
溶解度 | 易溶于水,溶于甲醇,几乎不溶于二氯甲烷。 |
形态 | 固体 |
颜色 | 白色到近乎白色 |
PH值 | pH (30g/l, 25℃) : 4.5~7.5 |
水溶解性 | Freely soluble in water |
Merck | 14,6904 |
BRN | 4287093 |
CAS 数据库 | 7240-38-2(CAS DataBase Reference) |
Oxacillin sodium monohydrate (Methicillin)是一种抗菌剂,是一种窄谱,青霉素类的β-内酰胺类抗生素。
Oxacillin exhibits MIC values of ≤1 μg/mL for four
mecA
gene-carrying
S. aureus
clinical isolates (SA 1306, SA 1326, SA 1552, and SA 4666.
Oxacillin (5 μg/mL, 0-90 min) induces lysis of Tol
+
and Tol
-
strains.
Cell Viability Assay
Cell Line: | Cells of S. aureus which had grown for six to eight generations in [ 14 C]glycerol. |
Concentration: | 5 μg/mL. |
Incubation Time: | 0, 30, 60, 90 min. |
Result: | The Tol + isolates were readily distinguished from Tol- isolates by the rates at which the cells lysed. |
化学性质
白色结晶性粉末。熔点188℃(分解),易溶于水、甲醇、二甲基亚砜,微溶于水乙醇、氯仿,极微溶于丙酮、丁醇,不溶于乙醚、苯。用途
半合成的耐酸耐酶青霉素。临床主要用于耐药金葡菌感染,如败血症、肺炎、化脓性脑膜炎和骨髓炎等。生产方法
6-氨基青霉烷酸与苯甲异噁唑酰氯缩合、成盐而得。安全信息
危险品标志 | Xn,Xi |
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危险类别码 | 36/37/38-42/43 |
安全说明 | 22-26-36/37 |
WGK Germany | 3 |
海关编码 | 29411099 |
毒性 | LD50 orally in rats: >8000 mg/kg (Goldenthal) |