1,1,1-TRIFLUORO-PENTAN-2-ONE synthesis
- Product Name:1,1,1-TRIFLUORO-PENTAN-2-ONE
- CAS Number:383-56-2
- Molecular formula:C5H7F3O
- Molecular Weight:140.1
3854-50-0
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Yield:383-56-2 75.2%
Reaction Conditions:
with butyric acid at -5 - 110;Reagent/catalyst;
Steps:
1 Synthesis of 1,1,1-trifluoro-2-pentanone
Synthesis of 1,1,1-trifluoro-2-pentanone, to 100ml of four-necked flask were successively added 36g (94. 2%) of 2-ethyl-4,4,4-trifluoroacetoacetic acid ethyl ester, 7.2g g Amberlyst-15 cation exchange resin, 36g n-butyric acid, using distillation apparatus, the temperature was kept at -5°C , stirred and heated to 100-110°C, distilled to produce crude 1,1,1-trifluoro-2-pentanone, to 2-ethyl-4,4,4-trifluoroacetoacetic acid ethyl ester < 1%, cooled, obtaining a colorless transparent liquid crude product , distilled to obtained 16.7g 1,1,1-trifluoro-2-pentanone, 75.2% yield, purity: 98.40% (GC).
References:
CN103214355,2016,B Location in patent:Paragraph 0074
353-85-5
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383-56-2
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