1-(1-methyl-3-pyrrolidinyl)-1H-pyrazol-4-amine synthesis
- Product Name:1-(1-methyl-3-pyrrolidinyl)-1H-pyrazol-4-amine
- CAS Number:1356953-69-9
- Molecular formula:C8H14N4
- Molecular Weight:166.22
1383706-07-7
0 suppliers
inquiry
1356953-69-9
6 suppliers
inquiry
Yield:1356953-69-9 100%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethanol; for 16 h;
Steps:
21.c (C) 1-(1-Methylpyrrolidin-3-yI)- 1H-pyrazol-4-amine (A24)
(C) 1-(1-Methylpyrrolidin-3-yI)- 1H-pyrazol-4-amine (A24)A solution of 1-(1-methylpyrrolidin-3-yl)-4-nitro-1 H-pyrazole A23 (0.575 g, 2.93 mmol) and 10% Pd/C (0.061 g) in EtOH (15 mL) was stirred under a hydrogen atmosphere for 16 hours. The reaction mixture was filtered through Celite and the solvent wasremoved in vacuo to give the title compound A24 as a red oil (0.555 g, quantitative).1H NMR (300 MHz, MeOD) O 2.27-2.42 (m, 1H), 2.72- 2.76 (m, 2H), 3.02- 3.10 (m,1H), 3.46-3.55 (m, 1H), 3.70-3.85 (m, 4H), 5.14-5.26 (m, 1H), 7.33 (5, 1H), 7.46(m, 1H).
References:
WO2014/26243,2014,A1 Location in patent:Page/Page column 125
1029413-53-3
34 suppliers
$41.00/250mg
1356953-69-9
6 suppliers
inquiry
13220-33-2
320 suppliers
$11.00/1g
1356953-69-9
6 suppliers
inquiry
91832-73-4
2 suppliers
inquiry
1356953-69-9
6 suppliers
inquiry